Synthesis and neurotropic activity of 6-thio-substituted pyrano[3,4-c]pyridine and 1-aminopyrano[4,3-d]-thieno[2,3-b]pyridine derivatives and 9-substituted pyrido[2,3-b]thieno[3,2-d]pyrimidines

Author： Paronikyan E.   Akopyan Sh.   Noravyan A.   Dzhagatspanyan I.   Nazaryan I.   Akopyan A.  

Publisher： Springer Publishing Company

ISSN： 0091-150X

Source： Pharmaceutical Chemistry Journal, Vol.44, Iss.4, 2010-08, pp. : 183-185

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Abstract

Methods for the synthesis of condensed thieno[3,2-d]pyrimidines based on 3,3-dimethyl-8-morpholino-6thioxo-3,4,6,7-tetrahydro-1H-pyrano[3,4-c]pyridine-5-yl cyanide have been developed. The neurotropic properties of the synthesized compounds have been investigated. Compounds possessing anticonvulsant activity and sedative properties are found. These compounds also exhibit an activating effect that makes them analogous to the well-known drug diazepam.

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