Author： Kirik O. Sukhorukova E. Korzhevskii D.
Publisher： Springer Publishing Company
ISSN： 0097-0549
Source： Neuroscience and Behavioral Physiology, Vol.41, Iss.2, 2011-02, pp. : 149-152
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Calcium-binding protein Iba-1 is currently believed to be identical to AIF-1 protein and is regarded as a selective marker for microglia. However, data on populations of cells able to express Iba-1/AIF-1 are contradictory. The aim of the present work was to identify rat brain cells expressing Iba-1 protein and to describe their functional characteristics. Immunocytochemical and confocal laser microscopy methods were used. Iba-1 protein was seen only in microglial cells, meningeal macrophages, supraependymal macrophages, and superficial and stromal cells of the vascular plexus, i.e., cells with phagocytic functions. Comparison of these data with results from other studies suggests that not all of the currently used antibodies to Iba-1/AIF-1 protein recognize the same product. This may be associated with alternative splicing of the Iba-1 mRNA.
Related content
By González Iván Arévalo-Serrano Juan Sanz-Anquela José Gonzalo-Ruiz Alicia
Acta Neuropathologica, Vol. 113, Iss. 6, 2007-06 ,pp. :
Access to resources
Recommend
By Vogt L. Schrimpf S.P. Meskenaite V. Frischknecht R. Kinter J. Leone D.P. Ziegler U. Sonderegger P.
Molecular and Cellular Neuroscience, Vol. 17, Iss. 1, 2001-01 ,pp. :
By Hwang In Yoo Ki-Yeon Kim Dae Choi Soo Kang Tae-Cheon Kim Yong-Sun Won Moo
Neurochemical Research, Vol. 31, Iss. 7, 2006-07 ,pp. :
By Ubeda-Bañon Isabel Saiz-Sanchez Daniel Rosa-Prieto Carlos Argandoña-Palacios Lucia Garcia-Muñozguren Susana Martinez-Marcos Alino
Acta Neuropathologica, Vol. 119, Iss. 6, 2010-06 ,pp. :