Author： Motaleb M. Alabdullah E. Zaghary W.
Publisher： Springer Publishing Company
ISSN： 0236-5731
Source： Journal of Radioanalytical and Nuclear Chemistry, Vol.287, Iss.1, 2011-01, pp. : 61-67
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
2,2′-[(8-hydroxyquinolin-7-yl)methylazanediyl]diacetic acid (HQMADA) was synthesized via reaction of 8-hydroxyquinoline with iminodiacetic acid in presence of paraformaldehyde with a yield of 27%. The obtained compound was well characterized via different analytical techniques. Labeling of the synthesized compound with technetium-99m in pertechnetate form (99mTcO4−) in the presence of stannous chloride dihydrate was carried out via chelation reaction. The reaction parameters that affect the labeling yield such as HQMADA concentration, stannous chloride dihydrate concentration, pH of the reaction mixture, and reaction time were studied to optimize the labeling conditions. Maximum radiochemical yield of 99mTc-HQMADA complex (91.9%) was obtained by using 1.5 mg HQMADA, 50 μg SnCl2·2H2O, pH 8 and 30 min reaction time. Biodistribution studies in mice were carried out in experimentally induced infection in the left thigh using
Related content
By Ibrahim I. Motaleb M. Attalah K.
Journal of Radioanalytical and Nuclear Chemistry, Vol. 285, Iss. 3, 2010-09 ,pp. :
Access to resources
Recommend
By Liu Miao Lin Xiao Song Xiaoqing Cui Yang Li Peiwen Wang Xuebin Zhang Junbo
Journal of Radioanalytical and Nuclear Chemistry, Vol. 298, Iss. 3, 2013-12 ,pp. :
By EL-Ghany E. A. Amine A. M. EL-Sayed A. S. EL-Kolaly M. T. Abdel-Gelil F.
Journal of Radioanalytical and Nuclear Chemistry, Vol. 266, Iss. 1, 2005-10 ,pp. :