Author: Suzuki Hideo Shoda Junichi Kawamoto Toru Shinozaki Eiji Miyahara Naoki Hotta Souichi Iizuka Yasushi Nakahara Akira Tanaka Naomi Yanaka Akinori Irimura Tatsuro
Publisher: Springer Publishing Company
ISSN: 0262-0898
Source: Clinical and Experimental Metastasis, Vol.21, Iss.4, 2004-10, pp. : 321-329
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Abstract
To address the need for new prognostic parameters in advanced colon carcinoma that could add insights into the aggressiveness of tumors, the expression levels of MUC1 recognized by a monoclonal antibody (mAb) MY.1E12 in archival specimens from 123 Japanese patients with colon carcinomas were evaluated by immunohistochemistry to correlate the results with clinicopathological characteristics. The localization of mAb MY.1E12-reactive-MUC1 (MY.1E12-MUC1) was classified into apical, cytoplasmic and stromal types based on the predominant cellular distribution. The MUC1 mRNA levels revealed by