Author： Müller F.U. Neumann J. Schmitz W.
Publisher： Springer Publishing Company
ISSN： 0300-8177
Source： Molecular and Cellular Biochemistry, Vol.212, Iss.1-2, 2000-09, pp. : 11-17
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Abstract
Stimulation of the cAMP-dependent signalling pathway by &bgr;-adrenergic catecholamines is an important physiological mechanism to increase contractile force in the heart. In addition to this, long-term &bgr;-adrenergic stimulation by elevated catecholamines also influences the expressional control of functionally relevant cardiac regulatory proteins in human heart failure. The regulation of transcription by the cAMP-response element (CRE) is an important mechanism for a cAMP-mediated control of gene expression involved e.g. in spermiogenesis and memory/learning processes. This article discusses recent data leading to the hypothesis that this mechanism also contributes to altered gene regulation in heart failure.
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