Molecular Cloning, Expression and Chromosomal Localization of Mouse MM-1

Author: Inazu Tetsuya   Myint Zaw   Kuroiwa Asato   Matsuda Yoichi   Noguchi Tamio  

Publisher: Springer Publishing Company

ISSN: 0301-4851

Source: Molecular Biology Reports, Vol.32, Iss.4, 2005-12, pp. : 273-279

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Abstract

The protooncogene product Myc associates with many proteins. The isolation of the mouse MM-1; c-Myc binding protein (Myc-Modulator 1) cDNA is described. The cDNA contains a 462 bp open reading frame that encodes a polypeptide of 154 amino acid residues. The deduced amino acid sequence indicates that mouse MM-1 has a 99% identity with the sequence of human MM-1. The expression of mouse MM-1 mRNA was detected in the fetal liver, but its level was 3-fold higher than that in the normal adult liver, and was slightly increased after a partial hepatectomy. It is expressed widely in a variety of adult mouse tissues. Thus, MM-1 may play a role in liver development and growth. A bioinformatics analysis indicates that mouse MM-1 gene consists of 6 exons. Furthermore, the chromosomal location of the mouse MM-1 gene was on the F2-F3 band of chromosome 15, as determined by fluorescence in situ hybridization.

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