Apoptotic and Non-apoptotic Caspase Functions in Neural Development

Author： Miura Masayuki  

Publisher： Springer Publishing Company

ISSN： 0364-3190

Source： Neurochemical Research, Vol.36, Iss.7, 2011-07, pp. : 1253-1260

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

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Abstract

During neural development, massive cell death occurs in both vertebrates and invertebrates. Caspase is a central player in apoptosis that is evolutionally conserved. Genetic manipulation of the caspase activity in Drosophila and mice has revealed that caspases control cell fate through apoptotic and non-apoptotic mechanisms, to ensure appropriate cell differentiation and maturation in the developing nervous system.

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