Author: Saluk-Juszczak Joanna Olas Beata Wachowicz Barbara Glowacki Rafal Bald Edward
Publisher: Springer Publishing Company
ISSN: 0742-2091
Source: Cell Biology and Toxicology, Vol.26, Iss.4, 2010-08, pp. : 355-365
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The oxidative stress induced by acute exertion may interfere with blood platelet activation. The beneficial effect of l-carnitine (γ-trimethylamino-β-hydroxybutyric acid) on oxidative stress in blood platelets has not been fully investigated; however, different studies indicate that this compound modulates platelet functions. The aim of our study was to assess the effects of l-carnitine on platelet activation and oxidative/nitrative protein damage (determined by the levels of protein carbonyl groups, thiol groups, and 3-nitrotyrosine residues) in resting blood platelets or platelets treated with peroxynitrite (ONOO−, a strong physiological oxidant) in vitro. We also investigated the effects of l-carnitine on the level of platelet glutathione and on the formation of superoxide anion radicals
Related content
By Haripriya Dayalan Devi Muthuswamy Anusuya Kokilavani Vedagiri Sangeetha Purushotham Panneerselvam Chinnakannu
Biogerontology, Vol. 5, Iss. 5, 2004-01 ,pp. :