An efficient synthesis of a rationally designed 1,5 disubstituted imidazole AT1 Angiotensin II receptor antagonist: reorientation of imidazole pharmacophore groups in losartan reserves high receptor affinity and confirms docking studies

Author： Agelis George   Roumelioti Panagiota   Resvani Amalia   Durdagi Serdar   Androutsou Maria-Eleni   Kelaidonis Konstantinos   Vlahakos Demetrios   Mavromoustakos Thomas   Matsoukas John  

Publisher： Springer Publishing Company

ISSN： 0920-654X

Source： Journal of Computer-Aided Molecular Design, Vol.24, Iss.9, 2010-09, pp. : 749-758

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