Author: Otahbachi Mohammad Simoni Jan Simoni Grace Moeller John Cevik Cihan Meyerrose Gary Roongsritong Chanwit
Publisher: Springer Publishing Company
ISSN: 0929-5305
Source: Journal of Thrombosis and Thrombolysis, Vol.30, Iss.2, 2010-08, pp. : 184-191
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Abstract
This study evaluated gender variability in platelet aggregation in response to common agonists. Platelet aggregation was measured in 36 healthy men and women free of any antiplatelet medication, aged 22–36 years, of Caucasian (White not of Hispanic origin), Hispanic, and African-American not of Hispanic origin. In this ex-vivo study, we investigated platelet aggregation in response to adenosine-5′-diphosphate (ADP), epinephrine (EPI), arachidonic acid (AA) and collagen (COL), using a platelet ionized calcium aggregometer (Chrono-Log Co.). Platelet aggregation response to all tested agonists was higher in females than in males regardless of ethnicity. The most significant differences were observed with collagen (
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