Identification of Genes Predisposing to Clinically Severe Obesity: An Approach

Author: North Michael   Jacobs J   Murphy Leo   Rumsey Eugene   Tanaka Laurence   Zorn George   Joslyn Geoff   Lou Walen Mary  

Publisher: Springer Publishing Company

ISSN: 1708-0428

Source: Obesity Surgery, Vol.5, Iss.3, 1995-08, pp. : 319-322

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Abstract

Background: Familial correlations, twin studies and adoption studies have all indicated that human obesity has a substantial genetic component. To date, obesity genes have only been identified using mouse models. Methods: In an attempt to identify human obesity genes large numbers of multigenerational families, in whom extreme obesity segregates, are currently being collected. Results and Conclusions: Relative risk estimates and models of genetic heterogeneity indicate that at least 500 affected sibling pairs will need to be collected to identify major genes.