Author: North Michael Jacobs J Murphy Leo Rumsey Eugene Tanaka Laurence Zorn George Joslyn Geoff Lou Walen Mary
Publisher: Springer Publishing Company
ISSN: 1708-0428
Source: Obesity Surgery, Vol.5, Iss.3, 1995-08, pp. : 319-322
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Abstract
Background: Familial correlations, twin studies and adoption studies have all indicated that human obesity has a substantial genetic component. To date, obesity genes have only been identified using mouse models. Methods: In an attempt to identify human obesity genes large numbers of multigenerational families, in whom extreme obesity segregates, are currently being collected. Results and Conclusions: Relative risk estimates and models of genetic heterogeneity indicate that at least 500 affected sibling pairs will need to be collected to identify major genes.
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