Author： Yilmaz Bilal Akba Vedat
Publisher： Taylor & Francis Ltd
ISSN： 0003-2719
Source： Analytical Letters, Vol.42, Iss.18, 2009-12, pp. : 2978-2985
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
This paper describes two rapid, sensitive, and specific methods for the determination of medazepam with internal standard (diazepam) in pharmaceutical preparations by gas chromatography (GC) with flame ionization (FID) and mass spectrometric (MS) detection. The linearity was established over the concentration range of 0.25-5 µg/mL for GC-FID and 50-1000 ng/mL for GC-MS method. The intra- and inter-day relative standard deviation was less than 2.94 and 4.95%, respectively. Developed GC-FID and GC-MS methods in this study are accurate, sensitive, and precise and can be directly and easily applied to Tranko buskas as pharmaceutical preparation.
Related content
By Koryagina Nadezhda Savelieva Elena Khlebnikova Natalia Goncharov Nikolay Jenkins Richard Radilov Andrey
Analytical and Bioanalytical Chemistry, Vol. 386, Iss. 5, 2006-11 ,pp. :
Access to resources
Recommend
By Pujos E. Cren-Olivé C. Goetinck P. Flament-Waton M. M. Grenier-Loustalot M. F.
Analytical Letters, Vol. 45, Iss. 4, 2012-03 ,pp. :
Access to resources