Author: Chun Moon Woo Lee Hyouk Woo Kim Ae Yil Kim Myong Jung Kim Hea Ok Gao Zhan-Guo Jacobson Kenneth Jeong Lak Shin
Publisher: Taylor & Francis Ltd
ISSN: 1525-7770
Source: Nucleosides, Nucleotides & Nucleic Acids, Vol.24, Iss.5-7, 2005-10, pp. : 1119-1121
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Abstract
Novel 3′-ureidoadenosine analogues were synthesized from 1,2:5,6-di- O -isopropylidene-d-glucose in order to lead to stronger hydrogen bonding at the A 3 adenosine receptor than the corresponding 3′-aminoadenosine derivatives. However, all synthesized 3′-ureidoadenosine analogues have lost their binding affinities to the all subtypes of adenosine receptors, indicating that bulky 3′-urea moiety led to conformational distortion.
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