Synthesis of 3′-Ureidoadenosine Analogues and their Binding Affinity to the A 3 Adenosine Receptor

Author: Chun Moon Woo   Lee Hyouk Woo   Kim Ae Yil   Kim Myong Jung   Kim Hea Ok   Gao Zhan-Guo   Jacobson Kenneth   Jeong Lak Shin  

Publisher: Taylor & Francis Ltd

ISSN: 1525-7770

Source: Nucleosides, Nucleotides & Nucleic Acids, Vol.24, Iss.5-7, 2005-10, pp. : 1119-1121

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Abstract

Novel 3′-ureidoadenosine analogues were synthesized from 1,2:5,6-di- O -isopropylidene-d-glucose in order to lead to stronger hydrogen bonding at the A 3 adenosine receptor than the corresponding 3′-aminoadenosine derivatives. However, all synthesized 3′-ureidoadenosine analogues have lost their binding affinities to the all subtypes of adenosine receptors, indicating that bulky 3′-urea moiety led to conformational distortion.

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