G-Octamer Formation from N9-Modified Guanine Derivatives

Author: McCallum Jeremy   Amare Solomon   Nolan Rebecca  

Publisher: Taylor & Francis Ltd

ISSN: 1525-7770

Source: Nucleosides, Nucleotides & Nucleic Acids, Vol.29, Iss.11-12, 2010-11, pp. : 801-808

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

The properties of the self-assembly of two lipophilic guanine derivatives, 2',3',5'-O-tris(tert-butyldimethylsilyl)-guanosine and N9-(3,5-bis(tert-butyldimethylsilyloxy)-benzyl)-guanine, are described. In the presence of K+, both guanine derivatives self-associate into D4-symmetric octamers consisting of two G-quartets stacked around a central ion.

Related content