Mammalian Genomics

Author: Ruvinsky   A.; Marshall Graves   J.A.  

Publisher: CABI Publishing‎

Publication year: 2004

E-ISBN: 9780851990750

P-ISBN(Hardback):  9780851999104

Subject: Q953 animal genetics

Keyword: Zoology and Animal Sciences Animal Husbandry Animal Breeding

Language: ENG

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Description

Genomics has experienced a dramatic development during the last 15-20 years. Data from mammalian genomes such as the human, mouse and rat have already been published, while others such as the dog, cattle and chimpanzee will soon follow. This book summarizes the current knowledge of mammalian genomics and offers a comparative analysis of genomes known today. This analysis includes farm, companion and lab animals. Topics covered include structural and functional aspects of the mammalian genome, mechanisms of genomic changes at the molecular level, evolution of DNA sequences, comparative chromosome mapping and painting, genome databases, gene prediction and the use of genomic information to understand inherited diseases. Contributors include leading researchers from Europe, USA, Australia and Japan.

Chapter

2. Mapping Genomes at the Chromosome Level

3. Mapping Genomes at the Molecular Level

4. DNA Sequence of the Human and Other Mammalian Genomes

5. The Transcriptome

6. The Proteome

7. The Epigenome: Epigenetic Regulation of Gene Expression in Mammalian Species

8. Regulation of Genome Activity and Genetic Networks in Mammals

9. Inducing Alterations in the Mammalian Genome for Investigating the Functions of Genes

10. A Comparative Analysis of Mammalian Genomics: Prokaryote and Eukaryote Perspectives

11. Elements and Mechanisms of Genome Change

12. DNA Sequence Evolution and Phylogenetic Footprinting

13. Evolution of the Mammalian Karyotype

14. Comparative Gene Mapping, Chromosome Painting and the Reconstruction of the Ancestral Mammalian Karyotype

15. Bioinformatics: From Computational Analysis through to Integrated Systems

16. Genetic Databases

17. Gene Predictions and Annotations

18. Genomic Research and Progress in Understanding Inherited Disorders in Humans and Other Mammals

19. Pharmacogenomics

20. Genome Scanning for Quantitative Trait Loci

21. Mammalian Population Genetics and Genomics

Index

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