Contents

Contributors

1 The Impact of Giardia on Science and Society

2 Cryptosporidium in Cattle: From Observing to Understanding

TAXONOMY, NOMENCLATURE AND EVOLUTION

3 Names Do Matter

4 Centenary of the Genus Cryptosporidium: From Morphological to Molecular Species Identification

MOLECULAR EPIDEMIOLOGY AND TYPING

5 Molecular Epidemiology of Human Cryptosporidiosis in Developing Countries

6 Molecular Epidemiology and Typing of Non-human Isolates of Cryptosporidium

7 Insights Into the Molecular Detection of Giardia duodenalis: Implications for Epidemiology

ZOONOTIC, HUMAN AND ANIMAL HEALTH ISSUES

8 Wildlife with Giardia: Villain, or Victim and Vector?

9 The Role of Livestock in the Foodborne Transmission of Giardia duodenalis and Cryptosporidium spp. to Humans

10 The Risk of Zoonotic Genotypes of Cryptosporidium spp. in Watersheds

CLINICAL AND MOLECULAR EPIDEMIOLOGY

11 Clinical Presentation in Cryptosporidium-infected Patients

12 Molecular Epidemiology of Cryptosporidium and Giardia Infections

ADVANCES IN DIAGNOSIS

13 Advances in Diagnosis: is Microscopy Still the Benchmark?

TREATMENT OF DRINKING WATER

14 Control of Cryptosporidium and Giardia in Surface Water by Disinfection

15 Towards Methods for Detecting UV-induced Damage in Individual Cryptosporidium parvum and Cryptosporidium hominis Oocysts by Immunofluorescence Microscopy

CONTROL IN WATER

16 Effect of Environmental and Conventional Water Treatment Processes on Waterborne Cryptosporidium Oocysts

17 Methods for Genotyping and Subgenotyping Cryptosporidium spp. Oocysts Isolated During Water and Food Monitoring

18 Intervention in Waterborne Disease

OTHER WATERBORNE PROTOZOA

19 Occurrence and Control of Naegleria fowleri in Drinking Water Wells

20 Environmental Factors Influencing the Survival of Cyclospora cayetanensis

BASIC BIOLOGY

21 Recent Advances in the Developmental Biology and Life Cycle of Cryptosporidium

22 Basic Biology of Giardia lamblia: Further Studies on Median Body and Funis

23 Giardia intestinalis: a Microaerophilic Parasite with Mitochondrial Ancestry

METABOLOMICS AND TRANSCRIPTOME

24 Cytoskeleton-based Lipid Transport in a Parasitic Protozoan, Giardia lamblia

25 Signalling During Giardia Differentiation

GENOMICS

26 Preliminary Analysis of the Cryptosporidium muris Genome

PROTEOMICS

27 Proteomic Analyses in Giardia

28 Proteomic and Genomic Approaches to Understanding the ‘Power Plant’ of Cryptosporidium

BIOCHEMISTRY AND PHYSIOLOGY

29 Energy Metabolism and Carbon Flow in Cryptosporidium parvum

30 The Surface Protein Repertoires of Cryptosporidium spp. and Other Apicomplexans

31 Giardan: Structure, Synthesis, Regulation and Inhibition

CELL BIOLOGY AND SIGNALLING

32 Protein Kinase C in Giardia duodenalis: a Family Affair

33 Secretory Granule Biogenesis and the Organization of Membrane Compartments via SNARE Proteins in Giardia lamblia

34 Molecular Mechanisms of Cryptosporidium-induced Host Actin Cytoskeleton Dynamics

PATHOGENESIS AND HOST–PARASITE RELATIONSHIP

35 Pathogenic Mechanisms in Giardiasis and Cryptosporidiosis

36 Interferon-gamma (IFN-γ) in Immunological Control of Cryptosporidial Infection

37 Immune Response to Giardia Infection: Lessons from Animal Models

DRUG TREATMENT AND NOVEL DRUG TARGETS

38 Drug Treatment and Novel Drug Targets Against Giardia and Cryptosporidium

Index

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