Psychosocial Interventions for Genetically Influenced Problems in Childhood and Adolescence

Author： Richard Rende  

Publisher： John Wiley & Sons Inc‎

Publication year： 2014

E-ISBN: 9781118221990

P-ISBN(Paperback): 9781118016992

P-ISBN(Hardback):  9781118016992

Subject： R749.94 child psychosis

Language： ENG

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Description

How to weigh genetic factors while choosing the best psychosocial interventions

Psychosocial Interventions for Genetically Influenced Problems in Childhood and Adolescence explores empirically supported psychosocial interventions in light of our current understanding of the genome. It considers how interventions may be modified and enhanced as the products of genomic research continue to expand – and why they offer the most promise for making substantial gains in treatment and prevention.

Providing a clear, accessible assessment of our current knowledge, both of the genome and evidence based treatments, Psychosocial Interventions for Genetically Influenced Problems in Childhood and Adolescence provides practical advice to clinicians,policy makers, and others invested in treating young people who present with a variety of conditions including anxiety, depression, ADHD, autism, substance abuse, and dyslexia. Rende discusses the current understanding of genetic etiology of psychopathology, and explores the support, or lack thereof, for various modes of treatment in light of new genomic knowledge. The overall premise is that our advances in genetics will be put to best therapeutic use by fueling translational psychosocial interventions.

Key points raised include:

  • The need for treating children suffering today, rather than waiting for a biological "magic bullet"
  • Discussion of how empirically-supported interventions mesh with genetic vulnerabilities
  • Ways in which interventions may change as genetic research continues

Chapter

Psychosocial Interventions for Genetically Influenced Problems in Childhood and Adolescence

Contents

Preface

Acknowledgments

1 Prelude: Great Expectations

Aren’t Magic Bullets Possible?

So Aren’t Similar Successes Imminent?

What Will be the Yield of Genetic Research in Terms of Intervention?

Where Will All of This Lead?

2 Autism Spectrum Disorder: Can We Use Environmental Intervention to Reprogram Genetic Effects?

Genomic Approaches to ASD

Is There a New Fundamental Etiological Model of ASD?

Genomics, Complex Disorders, Hype, and Hope

Using the Environment to Reprogram the Effects of Genes

What’s Next?

References

3 Attention-Deficit/Hyperactivity Disorder and Reading Disorder: Illuminating How the Environment Shapes Highly Heritable Disorders

Genetic Models of ADHD and RD: Why Has Gene Discovery Been So Elusive?

Why Would the Environment be Important for Highly Heritable Disorders?

More Nuanced Models of Gene–Environment Interplay for ADHD and RD

The Promise of Psychosocial Interventions

Concluding Remarks

References

4 Conduct Problems and Substance Use: The Underappreciated Role of Shared Environmental Influences

Genetic Models of CP and SU

The Impact of Shared Environmental Influences

Getting Molecular About the Environment

A Developmental Gene–Environment Model

Family-Based Interventions and Genetic Epidemiology

Summary and Looking Ahead

References

5 Depression: The Importance of the Family as a Context for Gene Expression

High-Risk Studies of Offspring of Depressed Parents

Genetic Models of MDD

GxE Interaction and Depression

Depression in Adolescents and Children

Who Should be Treated in Families at Risk?

Implications of the Parental Treatment Studies

References

6 Pediatric Bipolar Disorder: Complex Phenotypes, Genotypes, and Environments

Current Thinking on the Genetics of BP

Is PBD an Early Manifestation of Genetic Risk to BP?

The Clinical Complexity of PBD

Emphasizing Psychosocial Interventions for PBD

Conclusions

References

7 Pediatric Anxiety Disorders: The Intersection of Genes and Environments

The Heterogeneity of Anxiety Disorders: Focusing on Anxiety-Related Behaviors in Childhood and Adolescence

Anxiety in the Family: The Intersection of Genes and Parenting

Genes, Environment, and Anxiety: Newer Methdologies

Concluding Remarks

References

8 The Future: Why Psychosocial Intervention Will Matter Even More

Future Genetic Research and the Conceptualization of Disorders

Genomics May Refine Diagnosis and Point to Tailored Interventions

Genomics Will Lead to Earlier Intervention

Genomics Will Accelerate the Development of Psychosocial Interventions

Will We Discover Magic Bullets?

Author Index

Subject Index

End User License Agreement

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