Tissue-Specific Vascular Endothelial Signals and Vector Targeting, Part A ：Part A ( Volume 67 )

Publication subTitle ：Part A

Publication series ：Volume 67

Author： Pasqualini Renata

Publisher： Elsevier Science‎

Publication year： 2009

E-ISBN: 9780080962467

P-ISBN(Paperback): 9780123750105

P-ISBN(Hardback): 9780123750105

Subject： Q2 Cytobiology;R3 Basic Medical

Language： ENG

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Description

The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. This thematic volume reviews the latest research findings in the area of vascular proteomics related to the receptors of the vascular endothelium, and expands insights into diseases that exhibit distinct vascular characteristics, including cancer, obesity, and inflammation.

* Provides contrasting roles of VEGF, giving researchers a better understanding of the underlying mechanisms of VEGF *Includes chapters that review research employing a variety of organisms, allowing researchers to compare and contrast *Focuses on material that translates basic research to real-life treatment applications, showing primary researchers how the basic science is being used in the clinical setting

Chapter

Front Cover

Advances in Genetics

Contents

Contributors

Chapter 1: Inhibition of Vascular Endothelial Growth Factor Receptor Signaling in Angiogenic Tumor Vasculature

I. Introduction

II. VEGF/VEGFR Signaling Pathway as a Target of Antiangiogenic Therapy

III. Strategies to Inhibit the VEGF/VEGFR Signaling

IV. Using VEGFR-2 for Targeted Delivery of Powerful Toxic Agents

V. Summary

References

Chapter 2: Adeno-Associated Viral Vectors and Their Redirection to Cell-Type Specific Receptors

I. Introduction

II. Capsid Modifications of AAV to Target Cellular Receptors

III. Selecting Novel AAV Vectors from Combinatorial Libraries

IV. Perspectives

References

Chapter 3: Tissue-Specific Targeting Based on Markers Expressed Outside Endothelial Cells

I. Introduction

II. Nonendothelial Tissue-Specific Targets of Systemically Administered Agents

III. Concluding Remarks and Future Directions

Acknowledgment

References

Chapter 4: Ligand-directed Cancer Gene Therapy to Angiogenic Vasculature

I. Introduction

II. Therapeutic Concepts in Cancer Gene Therapy

III. Vectors for Ligand-directed Gene Delivery

IV. Ligands for Targeting Angiogenic Vasculature

V. Conclusion

References

Index

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