Description
Handbook of Endocrine Investigations in Children serves as a guide to general pediatricians in the investigation of childhood disorders. This book discusses the widespread availability of commercially prepared growth hormone by recombinant DNA technology.
Organized into eight chapters, this book begins with an overview of the general principles of endocrine testing in children. This text then explores the anterior pituitary gland, which secretes several hormones, including growth hormones, thyroid stimulating hormone, adrenocorticotrophin, prolactin, luteinizing hormone, and follicle-stimulating hormone. Other chapters consider the thyroid function, which is divided into thyroid profile and definitive tests. This book discusses as well the investigations required to determine the causes of hypo-or hypercalcemia associated with either parathyroid disease or disordered vitamin D metabolism. The final chapter deals with the potential application of the methods of molecular biology to the study of endocrine diseases in children.
This book is a valuable resource for general pediatricians, pediatric endocrinologists, and endocrinologists.
Chapter
CHAPTER 1. General Principles of Endocrine Tests
COLLECTION OF BLOOD SAMPLES
COLLECTION OF URINE SAMPLES
COLLECTION OF SALIVA SAMPLES
LABELLING AND PROCESSING OF SAMPLES
NORMAL RANGES FOR HORMONE CONCENTRATIONS
THYROID STIMULATING HORMONE
GONADOTROPHIN-RELEASING HORMONE
COMBINED TEST OF ANTERIOR AND POSTERIOR PITUITARY FUNCTION
THE SHORT CHILD WITH POSSIBLE GH DEFICIENCY
1. DIAGNOSIS: DELAYED PUBERTY (MALE)
2. DIAGNOSIS: DELAYED PUBERTY (MALE)
3. DIAGNOSIS: DELAYED PUBERTY (MALE)
4. DIAGNOSIS: DELAYED PUBERTY (MALE
5. DIAGNOSIS: DELAYED PUBERTY (MALE) PREVIOUS HEAD INJURY
6. DIAGNOSIS: DELAYED PUBERTY (FEMALE)
7. DIAGNOSIS: ISOLATED GH DEFICIENCY
8. DIAGNOSIS: DELAYED PUBERTY 'PARTIAL' GH DEFICIENCY
9. DIAGNOSIS: CONGENITAL HYPOPITUITARISM
10. DIAGNOSIS: PANHYPOPITUITARISM SEPTO-OPTIC DYSPLASIA
11. DIAGNOSIS: GH DEFICIENCY (TEMPORARY) SECONDARY TO HYDROCEPHALUS
12. DIAGNOSIS: CRANIOPHARYNGIOMA PANHYPOPITUITARISM
13. DIAGNOSIS: NASAL RHABDOMYOSARCOMA PARTIAL GH DEFICIENCY(RADIATION-INDUCED)
14. DIAGNOSIS: PINEAL·GERMINOMA GH DEFICIENCY GONADOTROPHIN DEFICIENCY( RADIATION- INDUCED)
15. DIAGNOSIS: MEDULLOBLASTOMA (RADIATION-INDUCED)
16. DIAGNOSIS:HYPOGONADOTROPHIC HYPOGONADISMANOSMIA
17. DIAGNOSIS: IDIOPATHIC PRECOCIOUS PUBERTY (FEMALE)
18. DIAGNOSIS: CENTRAL DIABETES INSIPIDUSHEAD INJURY
19. DIAGNOSIS: EXTREME SHORT STATURE (non-endocrine cause) RING Y-CHROMOSOME ANOMALY
SUGGESTED PROTOCOL FOR INVESTIGATION OF CONGENITAL HYPOTHYROIDISM
1. DIAGNOSIS: CONGENITAL HYPOTHYROIDISM ECTOPIC SUBLINGUAL THYROID
2. DIAGNOSIS: CONGENITAL HYPOTHYROIDISM FALSE POSITIVE CREATINE KINASE TEST
3. DIAGNOSIS: PRIMARY HYPOTHYROIDISM DYSHORMONOGENESIS
4. DIAGNOSIS: PRIMARY HYPOTHYROIDISM AUTO-IMMUNE THYROIDITIS
5. DIAGNOSIS: AUTO-IMMUNE THYROIDITIS (HASHIMOTO'S). ALOPECIA AREATA
6. DIAGNOSIS: HYPERTHYROIDISM (GRAVES' DISEASE)
CHAPTER 4. Calcium, Parathyroid, Vitamin D
1. DIAGNOSIS: PRIMARY HYPERPARATHYROIDISM PARATHYROID ADENOMA
2. DIAGNOSIS: VITAMIN D RESISTANT(HYPOPHOSPHATAEMIC) RICKETS
3. DIAGNOSIS: PSEUDO-HYPOPARATHYROIDISM
CHAPTER 5. The Adrenal Gland
TESTS OF ADRENOCORTICAL FUNCTION (GLUCOCORTICOIDS)
TESTS OF ADRENOCORTICAL FUNCTION (MINERALOCORTICOIDS)
1. DIAGNOSIS: PITUITARY-DEPENDENT CUSHING'S DISEASE
2. DIAGNOSIS: SIMPLE EXOGENOUS OBESITY
3. DIAGNOSIS: ADDISON'S DISEASE
4. DIAGNOSIS: SALT-LOSING CONGENITAL ADRENAL HYPERPLASIA (MALE)21-HYDROXYLASE DEFICIENCY
5. DIAGNOSIS: SALT-LOSING CONGENITAL ADRENAL HYPERPLASIA 21-HYDROXYLASE DEFICIENCY
6. DIAGNOSIS: LATE-ONSET CONGENITAL ADRENAL HYPERPLASIA
7. DIAGNOSIS: CONGENITAL ADRENAL HYPERPLASIA 11ß-HYDROXYLASE DEFICIENCY
8. DIAGNOSIS: PHAEOCHROMOCYTOMA
DISORDERS OF SEXUAL DIFFERENTIATION
1. DIAGNOSIS: BILATERAL TESTICULAR TORSION PRIMARY HYPOGONADISM
2. DIAGNOSIS: BILATERAL CRYPTORCHIDISM
3. DIAGNOSIS: ISOLATED MICROPENIS
4. DIAGNOSIS: ISOLATED MICROPENIS
5. DIAGNOSIS: PUBERTAL GYNAECOMASTIA
6. DIAGNOSIS: COMPLETE ANDROGEN INSENSITIVITY SYNDROME ANDROGEN-RECEPTOR NEGATIVE
7. DIAGNOSIS: PARTIAL ANDROGEN INSENSITIVITY SYNDROME ANDROGEN-RECEPTOR POSITIVE
8. DIAGNOSIS: AMBIGUOUS GENITALIA MIXED GONADAL DYSGENESIS
9. DIAGNOSIS: DELAYED PUBERTY (FEMALE)RADIATION-INDUCED PRIMARY OVARIAN FAILURE
10. DIAGNOSIS: ACUTE MYELOID LEUKAEMIA SECONDARY LYMPHOMA RADIATION-INDUCED PRIMARY OVARIAN FAILURE
11. DIAGNOSIS: PREMATURE THELARCHE
12. DIAGNOSIS: PREMATURE THELARCHE
13. DIAGNOSIS: IDIOPATHIC HIRSUTISM
CHAPTER 7. The Endocrine Pancreas
1. DIAGNOSIS: PERSISTENT NEONATAL HYPOGLYCAEMIA NESIDIOBLASTOSIS
2. DIAGNOSIS: INSULIN-DEPENDENT DIABETES MELLITUS
3. DIAGNOSIS: SEVERE DIABETIC KETOACIDOSIS HYPERLIPAEMIA
CHAPTER 8. The Molecular Biology of Endocrine Disease
Handbook of Endocrine Investigations in Children
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