Chapter
1 A Functional Overview of the Immune System and Immune Components
Innate and Adaptive Immunity
Anatomy of the Immune System
Cells of the Immune System
First Line Defenders: The Myeloid Cells
Adaptive Avengers: The Lymphoid Cells
Cluster of Differentiation
2 The Inflammatory Response
Initiation of the Inflammatory Response
Role of Antibodies in Inflammation
Biological Functions of Complement
Activation and Directed Migration of Leukocytes
Pathogen Recognition and Cytokine Signaling
Feedback and Adaptation from a Distance
3 The B Lymphocyte and the Humoral Response
B Lymphocytes Produce Antibodies
Structural Characteristics of Immunoglobulins
Immunoglobulin Nomenclature
Biologic Properties of Antibody Isotypes
Kinetics of Antibody Response
Membrane-Bound Immunoglobulin
Development and Selection of Mature B Cells
Activation and Differentiation of B Cells
4 T Lymphocytes: Ringleaders of Adaptive Immune Function
T Lymphocytes: Specific and Long-Lasting Immunity
Antigen Recognition by T Cells: Requirement of Major Histocompatability Molecules
Events Involved in T Lymphocyte Activation
Role of T Cells in B Cell Activation
Cytotoxic T Cell Effectors
Innate Lymphocytes and Superantigens
5 How We Defend Against Infectious Agents
Immune Homeostasis and Pathogenic Organisms
Major Immune Defense Mechanisms Against Pathogens
Physical Barriers to Infection
Phagocytic and Endocytic Barriers
Microbial Motifs Detected Through Pattern-Recognition Receptors
Human Immunodeficiency Virus
Parasitic Infections (Helminths)
Evasion of Immune Response
6 Basic Disorders of Immune Function
Immunodeficiency Disorders
Genetic Basis for Primary Immunodeficiency
Chronic Granulomatous Disease
Leukocyte Adhesion Deficiency
Innate Pattern-Recognition Receptor Disorders
Adaptive Immune Disorders
X-Linked (Bruton’s) Agammaglobulinemia (X-LA)
Common Variable Immunodeficiency
Severe Combined Immunodeficiency
Treatment of Immunodeficiency Diseases
Immunodeficiency as a Predisposition to Disease
Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
7 Autoimmunity: Regulation of Response to Self
Homeostasis, Immune Regulation, and Autoimmunity
Etiology of Autoimmune Disease
Role of Autoantibodies and Self-Reactive T Lymphocytes in Autoimmune Disorders
Laboratory Tests for Autoimmunity
8 The Immune Hypersensitivities
The Hypersensitive Disorders
Type I Hypersensitivity: IgE-Mediated Immediate Hypersensitivity
Type II Hypersensitivity: Antibody-Mediated Cytotoxic Hypersensitivity
Type III Hypersensitivity: Immune Complex-Mediated Hypersensitivity
Type IV Hypersensitivity: Delayed-Type (Cell-Mediated) Hypersensitivity
Alternate Hypersensitivity Classifications
9 Vaccines and Immunotherapy
Principles of Vaccination
Basic Concepts of Protective Immunization
Age and Timing of Immunizations
Therapeutic Uses of Immunoglobulins
Other Ways of Modifying Immunity
Understanding Immune Defenses Against Cancers
Effector Mechanisms in Tumor Immunity
Natural Killer Cells and Innate Response to Tumor Cells
Adaptive Response to Tumor Cells
Escape Mechanisms of Tumor Elimination
Tumors of the Immune System
Immunodiagnosis and Immunotherapy
11 Transplantation Immunology
Tissue Histocompatibility
Natural Isohemagglutinins
Graft-Versus-Host Disease
Pre-Transplantation Histocompatibility Evaluation
Immunosuppressive Drugs to Prevent Allograft Rejection
Immunosuppressive Therapy
12 Assessment of Immune Parameters and Immunodiagnostics
Antibody–Antigen Reactions
Secondary Manifestations of Antibody–Antigen Binding
Solid-Phase Precipitation Assays
Ouchterlony Double Diffusion Assay
Enzyme-Linked Immunoadsorbent Assay
Detection of Cellular Antigens
Fluorescence-Activated Cell Sorting Analysis
Assays to Determine Immune Function
Lymphocyte Function Assays
Other Tools to Measure Immunological Status
Introductory Immunology
：Basic Concepts for Interdisciplinary Applications
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