Front Cover

International Review of Neurobiology

Copyright

Contents

Contributors

Preface

Chapter 1: Molecular Profiling of Striatonigral and Striatopallidal Medium Spiny Neurons: Past, Present, and Future

I. Introduction

II. Early Detection of Neuropeptides and GPCRs in Striatonigral and Striatopallidal MSNs

III. Current Methods for Molecular Profiling in the Two MSN Subtypes

IV. The Next Stage for Genetic Profiling of the Two MSNs

V. Use of BAC Transgenic Fluorescent Reporter Mice to Evaluate Molecular Pathways in the Two MSNs

VI. Cell Type-Specific Overexpression and Knockout Models

VII. Cell Type-Specific Mouse Models Evaluating Drug and Natural Reward

VIII. Cell Type-Specific Mouse Models Evaluating Motor Behaviors

IX. Cell Type-Specific Models Evaluating Protein Modifications

X. Conclusions

References

Chapter 2: BAC to Degeneration: Bacterial Artificial Chromosome (Bac)-Mediated Transgenesis for Modeling Basal Ganglia Neurodegenerative Disorders

I. Introduction

II. Concept and Advantages of the BAC Transgenesis Approach

III. Generation of the BAC Transgenic Mice via Homologous Recombination

IV. Technique Considerations and Possible Solutions

V. BAC Transgenic Models of Basal Ganglia Neurodegenerative Disorders

VI. BAC Transgenesis to Model Huntington's Disorder (HD)

VII. BAC Transgenesis to Model Parkinson's Disease (PD)

VIII. Modeling Neurodegenerative Diseases via BAC Transgenesis, A Future Perspective

References

Chapter 3: Behavioral Outcome Measures for the Assessment of Sensorimotor Function in Animal Models of Movement Disorders

I. Introduction

II. Sensorimotor Tests for Unilateral 6-OHDA Rat

III. Sensorimotor Tests for Genetic Mouse Models

Acknowledgements

References

Chapter 4: The Role of DNA Methylation in the Central Nervous System and Neuropsychiatric Disorders

I. Introduction

II. DNA Methylation and DNA Methyltransferase

III. DNA Methylation Mediates Gene Silencing

IV. Role of DNA Methylation in the CNS and Neuropsychiatric Disorders

V. Conclusion Remarks

References

Chapter 5: Heritability of Structural Brain Traits: An Endophenotype Approach to Deconstruct Schizophrenia

I. Introduction

II. Heritability of Brain Structure Phenotypes

III. Genes for Brain Structures in Healthy and Persons with Schizophrenia

IV. Limitations and Clinical Relevance of the Studies

Acknowledgments

References

Chapter 6: The Role of Striatal Nmda Receptors in Drug Addiction

I. Introduction

II. NMDA Receptors in the Striatum

III. Role of Glutamate and NMDA Receptors in Drug Addiction

IV. Neuropharmacological Studies and Clinical Implications

Acknowledgment

References

Chapter 7: Deciphering Rett Syndrome With Mouse Genetics, Epigenomics, and Human Neurons

I. Introduction

II. RTT Mouse Models

III. MeCP2 Expressions and Functions

IV. MeCP2 and Gene Expression

V. Posttranslational Modification of MeCP2

VI. Epigenomics

VII. Human Neuron-Based RTT Disease Model

VIII. Summary

References

Index

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