Human Growth Hormone

Author: Mason   A. Stuart  

Publisher: Elsevier Science‎

Publication year: 2013

E-ISBN: 9781483192963

P-ISBN(Paperback): 9780433203407

P-ISBN(Hardback):  9780433203407

Subject: R335 endocrine physiology

Language: ENG

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Description

Human Growth Hormone is a compendium of papers that discusses all aspects of human growth hormone (HGH) relevant in the treatment of dwarfs who are HGH deficient. This book discusses the approach of growth hormone treatment including the preparation of the hormone, its effect and interactions with other hormones, the methods used to detect growth hormone in human plasma, as well as its clinical applications. One author discusses the preparation of human growth hormone, its storage, method of bioassay, and procedures for ampouling HGH for clinical use. A couple of authors review the metabolic actions of HGH, namely, on the anabolic and skeletal systems, on carbohydrate and fat metabolism, and miscellaneous effects (renotropic, aldosterone, haematopoietic). One paper evaluates the treatment of dwarfism with HGH, and reports that in cases of HGH deficiency, the use of such treatment can be effective as long as the growth potential of the patient remains, and antibodies do not interfere with the treatment. The compendium can prove helpful for endocrinologists, genetic scientists, cellular microbiologists, and scientists involved in pharmacology and developmental anatomy.

Chapter

POINTS T O CONSIDER IN CHOOSING A METHOD

PROCEDURES FOR AMPOULING HGH FOR CLINICAL USE

PHYSICOCHEMICAL AND IMMUNOLOGIGAL PROPERTIES OF HUMAN GROWTH HORMONE

RELATIONSHIP BETWEEN HUMAN GROWTH HORMONE AND HUMAN PROLACTIN

MOLECULAR WEIGHTS OF GROWTH HORMONES FROM VARIOUS SPECIES

IMMUNOLOGICAL RELATIONS BETWEEN HGH AND GROWTH HORMONES FROM OTHER SPECIES

BIOLOGICAL SPECIFICITY OF HGH

EVIDENCE FOR RETENTION OF BIOLOGICAL ACTIVITY AFTER PARTIAL DIGESTION OF GROWTH HORMONE WITH PROTEOLYTIC ENZYMES

AMINO ACID COMPOSITION AND SEQUENCE OF HGH AND COMPARISON WITH RELATED PROTEIN HORMONES

APPENDIX

REFERENCES

Chapter Two. Metabolic Effects of Human Growth Hormone

INTRODUCTION

ANABOLIC EFFECTS

SKELETAL EFFECTS

FAT AND CARBOHYDRATE METABOLISM

MISCELLANEOUS EFFECTS

THE INFLUENCE OF OTHER HORMONES ON THE METABOLIC RESPONSE TO HGH

MECHANISM OF ACTION OF HUMAN GROWTH HORMONE

REFERENCES

Chapter Three. Interactions of Growth Hormone with other Hormones

GROWTH HORMONE AND OTHER PITUITARY HORMONES

GROWTH HORMONE AND THYROID HORMONES

GH AND PARATHYROID HORMONE

GH AND ADRENOCORTICAL HORMONES

GH AND ADRENAL MEDULLARY HORMONES

GH AND SEX STEROIDS

GH AND INSULIN

GH AND GLUCAGON

REFERENCES

Chapter Four. The Assay of Human Growth Hormone and its Clinical Application

INTRODUCTION

THE IMMUNOASSAY OF HGH

LEVELS OF PLASMA HGH IN HEALTH

CHANGES IN GROWTH HORMONE LEVELS IN DISEASE

GROWTH HORMONE IN SOME ENDOCRINE DISORDERS

PRACTICAL SCHEDULES FOR DIAGNOSTIC USE OF PLASMA HGH LEVELS

APPENDIX I

APPENDIX II

REFERENCES

ADDENDUM

Chapter Five. Antibodies to Human Growth Hormone

RUTH ILLIG

DETERMINATION AND CHARACTERIZATION OF HGH ANTIBODIES

INCIDENCE OF ANTIBODIES TO HGH

TIME OF THE APPEARANCE OF HGH ANTIBODIES

INFLUENCE OF HGH ANTIBODIES ON GROWTH RESPONSE TO HGH

ROLE OF HGH QUALITY ON THE FORMATION OF ANTIBODIES

HEREDITARY TENDENCY FOR THE FORMATION OF HGH ANTIBODIES

THERAPY OF ANTIBODY-INDUCED GROWTH INHIBITION

ACKNOWLEDGMENTS

REFERENCES

Chapter Six. Treatment of Dwarfism with HGH

MEASUREMENTS

INTERPRETATION OF AUXOLOGIGAL DATA

DIAGNOSIS

PATIENTS WITH GROWTH HORMONE DEFICIENCY

SELECTION OF PATIENTS FOR HGH THERAPY

SELECTION OF PREPARATION AND DOSAGE SCHEDULE

RESULTS OF TREATMENT WITH HGH

REFERENCES

Index

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