Front Cover

Dale's Principle and Communication between Neurones

Copyright Page

Preface

Table of Contents

List of Contributors

Chapter 1. What is Dale's Principle?

References

Chapter 2. Recent Concepts of Chemical Communication between Excitable Cells

Structural Relationships of Excitable Cells

The Proliferation of Putative Neurotransmitters

Co-existence of Transmitters and Neuromodulation

Local Regulatory Mechanisms

'Axon Reflexes'

'Trophic' Factors

Summary

References

Chapter 3. The Neuroendocrine Division of the Nervous System: APUD Cells as Neurones or Paraneurones

Introduction

The Composition of the Diffuse Neuroendocrine System

Developmental Aspects

Neuroendocrine Marker Studies

APUD Cells as Neurones or Paraneurones

Evolution and the DNES

Future Trends

References

Chapter 4. Evidence for Co-transmission by Specific Neurones

Introduction

Neurotransmitters and Neurotransmission

Usefulness of Invertebrate Preparations in Neurobiology

Evolvement of Neurotransmitters

Co-existence of Neurotransmitters in Invertebrate Neurones

Utilisation of Acetylcholine and Serotonin by the same Neurone

Nature of the CCK-like Material in the GSCs

Does CCK have a Specific Effect on Snail Neurones

Other Studies

Conclusion

Future Studies

References

Chapter 5. Dendrites as Sites of Storage and Release of Neurotransmitter Substances, an Extension of Dale's Principle

Introduction

The GABAergic Granule Cell Dendrite

The Dopaminergic Dendrites of the Substantia Nigra Neurones

Peptides in Peripheral (Dendritic) Branches of Primary Sensory Neurones

Conclusions

Acknowledgements

References

Chapter 6. Non-synaptic Interneuronal Communication: Physiological and Pharmacological Implication

Introduction

Interneuronal Modulation Between Noradrenergic and Cholinergic Neurones

Interaction Between Dopaminergic and Cholinergic Neurones

Interaction Between Serotonergic and Cholinergic Neurones

Interaction Between Serotonergic and Noradrenergic Neurones

Interaction Between Dopaminergic and Neurosecretory Neurones

Presynaptic Modulation of Transmitter Release

Non-conventional Release of Modulators

Discussion

References

Chapter 7. Regulation of Glutamatergic and GABAergic Neuronal Activity by Astroglial Cells

Introduction

Release Processes in Neurones and Astrocytes

Uptake Processes in Neurones and Astrocytes

Metabolism in Neurones and Astrocytes

Neurone—glial Interactions

Future Trends

References

Chapter 8. Early Events in Autonomie Neurone Development: the Cholinergic/Adrenergic Choice

Introduction

Adrenergic and Cholinergic Neurones: The Case of the Superior Cervical Ganglion

Autonomie Ganglion Formation from the Neural Crest: Multipotentiality of the Neurone Precursor Population

Environmental Factors Involved in the Differentiation of Autonomie Neuroblasts

Evidence for Early Cholinergic Differentiation in Neural Crest; Biochemical and Histochemical Studies

Cholinergic and Adrenergic Traits in Neural Crest Cells in Culture

Implications of Early Cholinergic Activity Linked to Peripheral Neurone Development

Neurotransmitter Plasticity in Autonomie Neurones

Concluding Remarks and Future Prospects

Acknowledgements

References

Chapter 9. Multiple Signais Participating in GAB A Receptor Modulation

Introduction

Supramolecular Structure of Transmitter Receptors

Evidence that GAB A Receptors may Include a Cotransmitter Recognition Site

Supramolecular Organization of GAB A Receptors

Putative Cotransmitters of GAB A Receptors

Conclusions

References

Chapter 10. The Use of Immunogold Staining Procedures in the Demonstration of Neurochemical Coexistence at the Ultrastructural Level

Introduction

Double or Multiple Immunostaining at the Light Microscope Level

Sub-cellular Storage Sites

Electron Immunocytochemistry

Appendix

References

Index