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The Molecular Biology of Neurological Disease

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Table of Contents

FOREWORD

PREFACE

CONTRIBUTORS

CHAPTER 1. Molecular Genetics and Neurological Disease: Basic Principles and Methods

INTRODUCTION

PRINCIPLES OF MENDELIAN INHERITANCE

STRUCTURE AND FUNCTION OF NUCLEIC ACIDS

THE MOLECULAR BASIS OF GENETIC VARIATION

GENE CLONING, GENE LIBRARIES, AND GENE PROBES

GENE MAPPING, GENE TRACKING AND NEUROLOGICAL DISEASE

WHAT NEXT AFTER GENETIC LINKAGE?

THE CLINICAL APPLICATION OF LINKED DNA MARKERS AND GENE SPECIFIC PROBES

GENE THERAPY

REFERENCES

CHAPTER 2. Genes expressed in the brain: evolutionary and developmental considerations

INTRODUCTION

THE COMPLEXITY OF GENE EXPRESSION IN THE BRAIN

GENE EXPRESSION AND POSTNATAL DEVELOPMENT OF THE BRAIN

RECOMBINANT DNA AND THE ISOLATION OF GENES SPECIFYING BRAIN PROTEINS

REFERENCES

CHAPTER 3. In situ hybridization: visualizing brain messenger RNA

INTRODUCTION

EXPRESSION OF GENES ENCODING BRAIN STRUCTURAL PROTEINS DURING DEVELOPMENT

REGULATION OF NEUROPEPTIDES RELATED TO CELL FUNCTION

ALZHEIMER DISEASE GENETICS

VIRUSES AND ALZHEIMER'S DISEASE

TECHNIQUES OF COMBINING IN SITU HYBRIDIZATION AND IMMUNOHISTOCHEMISTRY IN BRAIN TISSUE

CONCLUSIONS

ACKNOWLEDGEMENTS

REFERENCES

CHAPTER 4. Molecular biology of chemical neurotransmission

INTRODUCTION

NEUROTRANSMITTERS

NEUROTRANSMITTER RECEPTORS

NEUROPEPTIDE RECEPTORS

CONCLUSIONS

ACKNOWLEDGEMENTS

REFERENCES

CHAPTER 5. Proteins which regulate the development of the nervous system

INTRODUCTION

REGULATION OF CELL DIFFERENTIATION: NERVE GROWTH FACTOR

REGULATION OF CELL PROLIFERATION: PLATELET-DERIVED GROWTH FACTOR

REGULATION OF CELL–CELL ADHESION: NEURAL CELL ADHESION MOLECULE

REGULATION OF CELL–SUBSTRATUM ADHESION: LAMININ

REFERENCES

CHAPTER 6. Gene expression in skeletal muscle

INTRODUCTION

MOLECULAR CORRELATES OF MUSCLE DIFFERENTIATION

THE MYOFIBRILLAR PROTEINS

CONTROL OF MUSCLE GENE EXPRESSION

THE CELL SURFACE OF SKELETAL MUSCLE CELLS

REFERENCES

CHAPTER 7. Host and viral genetic factors which influence viral neurotropism

INTRODUCTION

HOST FACTORS INFLUENCING SUSCEPTIBILITY TO VIRAL INFECTION

VIRAL FACTORS

CONCLUSIONS

ACKNOWLEDGEMENTS

REFERENCES

CHAPTER 8. Neuro-oncogenesis: recessive genes, activated oncogenes, and chromosome abnormalities in the development of neuroectodermal cancers

INTRODUCTION

ONCOGENES

CHROMOSOMES AND CANCER

RECESSIVE GENES AND CANCER

SOMATIC CELL HYBRIDS, TRANSFECTION, AND TRANSGENIC MICE

TUMOUR REGRESSION, MATURATION, AND PROGRESSION

NEURO-ONCOGENESIS

CONCLUSIONS

REFERENCES

CHAPTER 9. Transgenic mice and neurological disease

INTRODUCTION

METHODS OF GENE TRANSFER INTO ANIMALS AND GENERAL CONSIDERATIONS ABOUT EXPRESSION

EXPRESSION OF VIRAL GENES WITH PATHOLOGICAL EFFECTS IN THE NERVOUS SYSTEM

EXPRESSION OF GENES NORMALLY ACTIVE IN THE NERVOUS SYSTEM OR SKELETAL MUSCLE

ECTOPIC EXPRESSION IN THE NERVOUS SYSTEM

INSERTIONAL MUT AGENESIS

CORRECTION OF GENETIC DEFECTS

TRANSGENIC MICE AS BIOASSAYS FOR EFFECTS OF DEFECTIVE GENES

REFERENCES

CHAPTER 10. Messenger RNA levels in neurological disease

INTRODUCTION

MESSENGER RNA ANALYSIS IN POSTMORTEM BRAIN

MESSENGER RNA LEVELS IN ALZHEIMER'S DISEASE

ACKNOWLEDGEMENTS

REFERENCES

CHAPTER 11. Molecular genetics of Joseph disease

AETIOLOGY OF JOSEPH DISEASE

AZOREAN NEUROEPIDEMIOLOGY

MOLECULAR GENETICS OF JOSEPH DISEASE

CONCLUSIONS

REFERENCES

CHAPTER 12. Huntington's disease

INTRODUCTION

DESCRIPTION OF THE DISEASE

THE MOLECULAR GENETIC APPROACH TO HUNTINGTON'S DISEASE

REFERENCES

CHAPTER 13. Molecular genetics and muscular dystrophy

INTRODUCTION

DUCHENNE AND BECKER MUSCULAR DYSTROPHIES

OTHER MUSCULAR DYSTROPHIES

CONCLUSIONS

REFERENCES

CHAPTER 14. Mitochondrial genes and neurological disease

ASPECTS OF MITOCHONDRIAL STRUCTURE AND FUNCTION

MITOCHONDRIAL GENETICS

References

CHAPTER 15. Molecular basis of retinoblastoma

INTRODUCTION

CHROMOSOMES IN RETINOBLASTOMA

ESTERASE D STUDIES

CONCLUSIONS

REFERENCES

CHAPTER 16. Detection of viral genes in neurological disease

INTRODUCTION

INTERACTION OF PERSISTENT VIRUS AND BRAIN

THE ROLE OF IMMUNOSUPPRESSION

EFFECTS OF PERSISTENT AND LATENT VIRUSES ON HOST CELL METABOLISM

DETECTION METHODS FOR VIRAL GENOME

VIRUSES OF SPECIAL INTEREST

DISEASES OF KNOWN VIRAL AETIOLOGY

SOME DISEASES OF POSSIBLE VIRAL AETIOLOGY

CONCLUSIONS

ACKNOWLEDGEMENTS

REFERENCES

CHAPTER 17. Immunogenetics: genetic polymorphism and susceptibility to neurological disease

INTRODUCTION

GENETICS OF IMMUNE RESPONSE

HLA AND DISEASE

MULTIPLE SCLEROSIS

MYASTHENIA GRAVIS

LAMBERT-EATON MYASTHENIC SYNDROME

THE NARCOLEPTIC SYNDROME

CONCLUSIONS

REFERENCES

CHAPTER 18. A neurological gene map

INTRODUCTION

REFERENCES

INDEX