Biotechnology in Growth Regulation

Author: Heap   R. B.;Prosser   C. G.;Lamming   G. E.  

Publisher: Elsevier Science‎

Publication year: 2013

E-ISBN: 9781483100838

P-ISBN(Paperback): 9780407014732

P-ISBN(Hardback):  9780407014732

Subject: Q959.8 Mammalia

Language: ENG

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Description

Biotechnology in Growth Regulation focuses on mechanisms of action of growth hormones and how immunological and transgenic procedures can affect growth response.
The book first examines species specificity and structure-function relationship of growth hormones. Microheterogeneity of growth hormones; variations in amino acid sequence and biological properties of growth hormones; and structure-function relationship are discussed. The text also looks at growth hormone receptors and binding proteins; regulation of growth hormone receptors; modulations of growth hormone release; and neuroregulation of growth hormone secretion. The book then discusses the role of growth hormones in the regulation of adipocyte growth and function. Chronic effects of growth hormones on insulin action and lipid synthesis; effects of growth hormones on lipolysis; and adipogenesis are also described.
The text looks at growth-promoting properties of recombinant growth hormones and mechanisms by which porcine growth hormone enhances growth in pigs. The book also highlights the direct effects of growth hormones on osteogenesis and chondrogenesis; action of IGF-I on mammary function; antigen-antibody complexes that enhance growth; and transgenics. The text also presents experiments that show the effects of growth hormones on animals.
The book is a good source of information for readers wanting to study growth hormones.

Chapter

SPECIES SPECIFICITY OF GROWTH HORMONES: VARIATIONS IN BIOLOGICAL PROPERTIES

STRUCTURE-FUNCTION RELATIONSHIPS

CONCLUSIONS

REFERENCES

Chapter 2. GROWTH HORMONE RECEPTORS AND BINDING PROTEINS

INTRODUCTION

RECEPTOR PURIFICATION AND CLONING

SERUM BINDING PROTEIN

HOMOLOGY WITH THE PROLACTIN RECEPTOR

PROSPECTIVE

ACKNOWLEDGEMENTS

REFERENCES

Chapter 3. THE REGULATION OF THE GROWTH HORMONE RECEPTOR

INTRODUCTION

HETEROGENEITY OF THE GH RECEPTOR

ONTOGENY OF GH RECEPTORS

ENDOCRINE AND METABOLIC REGULATION OF THE GH RECEPTOR

CONCLUDING REMARKS

ACKNOWLEDGEMENTS

REFERENCES

Chapter 4. MODULATION OF GROWTH HORMONE RELEASE: FROM CNS TO THE SECRETORY EVENT

INTRODUCTION

GHRH AND SS IN THE HYPOTHALAMUS

OTHER HYPOTHALAMIC FACTORS INFLUENCING GH RELEASE

CONTROL OF HYPOTHALAMIC PEPTIDES

EPISODIC GH RELEASE

SOMATOTROPHS, SECOND MESSENGERS AND ION CHANNELS

GHRH CONTROL OF GH RELEASE

SS CONTROL OF GH RELEASE

INTERRELATIONSHIPS BETWEEN GH SECRETING FACTORS

CODA

ACKNOWLEDGEMENTS

REFERENCES

Chapter 5. NEUROREGULATION OF GROWTH HORMONE SECRETION

INTRODUCTION

PEPTIDERGIC CONTROL OF GH RELEASE

FEEDBACK PATHWAYS AND CHOLINERGIC CONTROL

REFERENCES

Chapter 6. ROLE OF GROWTH HORMONE IN THE REGULATION OF ADIPOCYTEGROWTH AND FUNCTION

INTRODUCTION

RECEPTORS FOR GH AND IGFs

CHRONIC EFFECTS OF GH ON INSULIN ACTION AND LIPID SYNTHESIS

ACUTE, INSULIN-LIKE EFFECTS OF GH ON ADIPOCYTE METABOLISM

EFFECTS OF GH ON LIPOLYSIS

MEDIATION BY IGFs

ADIPOGENESIS

CONCLUSIONS

REFERENCES

Chapter 7. A COMPARISON OF THE MECHANISMS OF ACTION OF BOVINE PITUITARY-DERIVED AND RECOMBINANT SOMATOTROPIN (ST)IN INDUCING GALACTOPOIESIS IN THE COW DURING LATELACTATION

INTRODUCTION

EXPERIMENTAL

RESULTS AND DISCUSSION

COMMENT

ACKNOWLEDGEMENTS

REFERENCES

Chapter 8. GROWTH PROMOTING PROPERTIES OF RECOMBINANT GROWTH HORMONE

INTRODUCTION

THE PHYSIOLOGICAL ROLE OF ENDOGENOUS GH

EXOGENOUS GH: GROWTH AND BODY COMPOSITION

THE INTERACTION BETWEEN GH AND OTHER ANABOLIC HORMONES

THE EFFECTS OF GH ON METABOLISM BY SPECIFIC TISSUES

VARIABILITY OF RESPONSIVENESS TO EXOGENOUS GH

CONCLUSIONS: THE FUTURE

ACKNOWLEDGEMENTS

REFERENCES

Chapter 9. THE MECHANISMS BY WHICH PORCINE GROWTH HORMONE IMPROVES PIG GROWTH PERFORMANCE

INTRODUCTION

METABOLIC EFFECTS OF pGH

SOMATOGENIC EFFECTS OF pGH

SUMMARY

REFERENCES

Chapter 10. EVALUATION OF SOMETRIBOVE (METHIONYL BOVINE SOMATOTROPIN) IN TOXICOLOGY AND CLINICAL TRIALS IN EUROPE AND THEUNITED STATES

INTRODUCTION

TOXICOLOGY EXPERIMENTS

CLINICAL TESTING

FARM TRIALS

SOMETRIBOVE AND THE DETECTION OF TREATED COWS

CONCLUSION

REFERENCES

Part 2. GROWTH FACTORS

Chapter 11. GROWTH PROMOTION USING RECOMBINANT INSULIN-LIKE GROWTH FACTOR-I

INTRODUCTION

HYPOPHYSECTOMIZED RATS

YOUNG MINI-POODLES

SUMMARY AND CONCLUSIONS

REFERENCES

Chapter 12. THE DIRECT EFFECTS OF GROWTH HORMONE ON CHONDROGENESIS AND OSTEOGENESIS

INTRODUCTION

MECHANISTIC THEORIES OF GH ACTION

GH EFFECTS ON ORGAN CULTURE OF MANDIBULAR CONDYLES

GH EFFECTS IN TISSUE CULTURE OF CHONDROPROGENITOR CELLS

GH EFFECTS ON THE OSSIFICATION FRONT

GH EFFECTS ON THE BONE MARROW

CONCLUSIONS

ACKNOWLEDGEMENTS

REFERENCES

Chapter 13. GROWTH PROMOTION BY GROWTH HORMONE AND INSULIN-LIKE GROWTH FACTOR-I IN THE RAT

INTRODUCTION

THE HYPOPHYSECTOMIZED RAT

NORMAL RATS

IN VIVO GROWTH-PROMOTING EFFECTS OF IGF-I

STUDIES WITH GENETIC MUTANTS

DWARF RATS

CONCLUDING REMARKS

ACKNOWLEDGEMENTS

REFERENCES

Chapter 14. ACTION OF IGF-I ON MAMMARY FUNCTION

INTRODUCTION

ROLE OF INSULIN IN MAMMARY FUNCTION

IGF RECEPTORS

ROLE OF IGF-I IN MAMMARY FUNCTION IN VIVO

CONCLUDING REMARKS

ACKNOWLEDGEMENTS

REFERENCES

Chapter 15. CHANGES IN INSULIN AND SOMATOMEDIN RECEPTORS AND UPTAKEOF INSULIN, IGF-I AND IGF-II DURING MAMMARY GROWTH,LACTOGENESIS AND LACTATION

BACKGROUND

INSULIN

INSULIN-LIKE GROWTH FACTOR I

INSULIN-LIKE GROWTH FACTOR II

REFERENCES

PARTICIPANTS

Part 3. IMMUNOLOGICAL ENHANCEMENT

Chapter 16. ANTIGEN-ANTIBODY COMPLEXES THAT ENHANCE GROWTH

INTRODUCTION

MONOCLONAL ANTIBODIES

GH/MAb COMPLEXES AND GROWTH

GH/MAb COMPLEXES AND BODY COMPOSITION

GH/MAb COMPLEXES AND LACTOGENIC ACTIVITY

GH/MAb COMPLEXES AND RECEPTOR BINDING

COVALENT LINKING STUDIES

MECHANISM OF ENHANCEMENT

ENHANCEMENT OF GH ACTIVITY BY ACTIVE IMMUNIZATION

CONCLUSIONS

REFERENCES

Part 4. TRANSGENICS

Chapter 17. INSERTION OF GROWTH HORMONE GENES INTO PIG EMBRYOS

INTRODUCTION

INTEGRATION OF FUSION GENES

EXPRESSION OF INTEGRATED GENES

PERFORMANCE AND PHYSIOLOGICAL CHARACTERISTICS

TRANSMISSION OF TRANSGENES

CONCLUSIONS

REFERENCES

Chapter 18. INDUCED EXPRESSION OF A BOVINE GROWTH HORMONE CONSTRUCT INTRANSGENIC PIGS

INTRODUCTION

PRODUCTION OF TRANSGENIC PIGS

INTEGRATION OF TRANSGENE

EXPRESSION OF TRANSGENE

INDUCED EXPRESSION

COMMENT

REFERENCES

Part 5. ACCEPTABILITY OFBIOTECHNOLOGY

Chapter 19. CRITERIA FOR THE PUBLIC ACCEPTABILITY OF BIOTECHNOLOGICAL INNOVATIONS IN ANIMAL PRODUCTION

INTRODUCTION

CATEGORIES OF SOCIETY

PHYSIOLOGICAL CRITERIA

PROCEDURAL CRITERIA

RECOMMENDATIONS

CODA

REFERENCES

Part 6. POSTERS

Chapter 20. INDEX OF POSTERS

Chapter 21. STRUCTURE AND REGULATION OF THE RAT GROWTH HORMONE RECEPTOR

REFERENCE

Chapter 22. CLONING AND ANALYSIS OF EXPRESSION OF RAT GROWTH HORMONER ECEPTOR

Chapter 23. CONFORMATIONAL ANALYSIS OF BOVINE GROWTH HORMONE FRAGMENTS WHICH CORRESPOND TO HELICAL REGIONS OFTHE INTACT PROTEIN

REFERENCES

Chapter 24. BIOLOGICAL ACTIVITY OF AMINO-TERMINAL AMINO ACID VARIANTS OF BOVINE SOMATOTROPIN

REFERENCES

Chapter 25. PURIFICATION AND PROPERTIES OF TWO RECOMBINANT DNA-DERIVEDOVINE GROWTH HORMONE VARIANTS EXPRESSED IN ESCHERICHIA COLI

REFERENCES

Chapter 26. GH TREATMENT OF HYPOPHYSECTOMIZED RATS: HORMONE AND NUTRIENT INTERACTIONS ON TISSUE METABOLISM

Chapter 27. HUMAN GROWTH HORMONE TREATMENT ENHANCES DEPOSITION OFCOLLAGEN IN RAT SKELETAL MUSCLES

REFERENCES

Chapter 28. METABOLIC AND ENDOCRINE CHALLENGE OF SOMATOTROPIN TREATED PIGS

REFERENCES

Chapter 29. EFFECT OF SOMATOTROPIN ON NITROGEN AND ENERGY METABOLISM IN GROWING SWINE

REFERENCES

Chapter 30. ANTI-LIPOGENIC EFFECTS OF SOMATOTROPIN ON OVINE ADIPOSE TISSUE

REFERENCES

Chapter 31. INCREASES IN SHEEP ADIPOCYTE β-RECEPTOR NUMBER ON EXPOSURETO GROWTH HORMONE IN VITRO

REFERENCES

Chapter 32. THE EFFECT OF GROWTH HORMONE ON HIND-LIMB MUSCLEMETABOLISM IN GROWING LAMBS

Chapter 33. THE EFFECT OF GROWTH HORMONE ON MUSCLE ENZYME ACTIVITYAND LACTATE DEHYDROGENASE ISOENZYME PATTERN

REFERENCES

Chapter 34. THE EFFECTS OF CLOSE-ARTERIAL INFUSION OF CIMATEROL INTO THE HIND-LIMB OF GROWING LAMBS

REFERENCE

Chapter 35. MANIPULATION OF GROWTH IN ENTIRE MALE SHEEP BY THE BETAADRENERGIC AGONIST CIMATEROL AT TWO LEVELS OF DIETARY PROTEIN

Chapter 36. GROWTH HORMONE RELEASE IN CALVES SELECTED FOR HIGH ANDLOW DAIRY MERIT

REFERENCES

Chapter 37. THE INFLUENCE OF BOVINE SOMATOTROPIN (BST) ON LEUKOCYTEINSULIN RECEPTORS IN LACTATING COWS AND BEEF STEERS

REFERENCES

Chapter 38. BLOOD CONSTITUENTS AND SUBCUTANEOUS ADIPOSE TISSUE METABOLISM OF DAIRY COWS AFTER ADMINISTRATION OF RECOMBINANT BOVINE SOMATOTROPIN (bST) IN A PROLONGEDRELEASE FORMULATION

Chapter 39. THE EFFECT OF RECOMBINANT BOVINE SOMATOTROPIN (bST) IN ASUSTAINED RELEASE VEHICLE ON THE PERFORMANCE OF DAIRY COWS

Chapter 40. CHANGES IN MAMMARY UPTAKE OF ESSENTIAL AMINO ACIDS INLACTATING JERSEY COWS IN RESPONSE TO EXOGENOUS BOVINEPITUITARY SOMATOTROPIN

REFERENCE

Chapter 41. BIOCHEMICAL RESPONSES TO THE USE OF RECOMBINANT BOVINE SOMATOTROPIN (SOMETRIBOVE) IN DAIRY CATTLE IN RELATIONTO PRODUCTION AND WELFARE

REFERENCE

Chapter 42. ROLE OF FEVER ON THE ENDOTOXIN-INDUCED SOMATOTROPIN RELEASE IN THE LACTATING GOAT

ACKNOWLEDGEMENTS

REFERENCES

Chapter 43. EFFECTS OF RECOMBINANT PORCINE GROWTH HORMONE IN GERMAN PIG BREEDS DURING GROWTH AND LACTATION

Chapter 44. SEMISYNTHESIS OF INSULINS WITH MODIFIED GROWTH PROMOTING PROPERTIES

REFERENCES

Chapter 45. IDENTIFICATION OF THE PORCINE INSULIN-LIKE GROWTH FACTOR(IGF)I GENE PROMOTER REGION

REFERENCES

Chapter 46. STUDIES ON THE SECRETION OF HUMAN PROINSULIN AND INSULIN-LIKE GROWTH FACTORS I AND II IN E.COLI

REFERENCES

Chapter 47. INSULIN-LIKE GROWTH FACTOR (IGF) I AND II mRNA LEVELS IN THETISSUES OF THE OVINE FETUS AND NEONATE

REFERENCES

Chapter 48. LEVELS OF INSULIN-LIKE GROWTH FACTOR I IN SHEEP TISSUES

REFERENCES

Chapter 49. MODULATION OF INSULIN-LIKE GROWTH FACTOR I AND II mRNA DURING LOCALIZED GROWTH OF RAT SKELETAL MUSCLE AND BROWN ADIPOSE TISSUE

REFERENCES

Chapter 50. IDENTIFICATION OF IGF-I mRNA IN RABBIT MAMMARY GLAND AND EVOLUTION DURING PREGNANCY AND LACTATION

REFERENCES

Chapter 51. TISSUE-SPECIFIC AND DEVELOPMENTAL EXPRESSION OF INSULIN-LIKE GROWTH FACTOR-I IN THE PREGNANT AND LACTATING PIG

REFERENCES

Chapter 52. IGF-BINDING PROTEINS FROM PIG PRE-IMPLANTATION BLASTOCYSTS

REFERENCES

Chapter 53. INSULIN-DEPENDENCE OF THE SMALL IGF-BINDING PROTEIN (IGF-SBP)

Chapter 54. TRANSFER OF PLASMA IGF-I INTO LYMPH

REFERENCE

Chapter 55. GROWTH HORMONE (bST), INSULIN, INSULIN LIKE GROWTH FACTOR I(IGF-I) AND IGF-I BINDING PROTEINS DURING LACTATION INCATTLE

Chapter 56. THE EFFECT OF NUTRITIONAL STATUS AND GROWTH HORMONE (GH)TREATMENT ON THE IN VITRO MITOGENIC RESPONSES OF MAMMARY GLAND TISSUE IN LAMBS

Chapter 57. COMPARATIVE ASPECTS OF SELECTED HORMONES AND GROWTH FACTORS ON PROTEIN METABOLISM IN ADULT AND FETAL OVINE PRIMARY MUSCLE CULTURES

REFERENCE

Chapter 58. INDUCTION OF LACTOGENIC RECEPTORS IN HYPOPHYSECTOMIZED RATS TREATED WITH BOVINE GROWTH HORMONE-MONOCLONAL ANTIBODY COMPLEXES

REFERENCES

Chapter 59. POTENTIATION OF GROWTH HORMONE ACTIVITY USING A POLYCLONAL ANTIBODY OF RESTRICTED SPECIFICITY

Chapter 60. PROTEINS COVALENTLY LINKED TO HUMAN GROWTH HORMONE WILLENHANCE ITS ACTIVITY IN VIVO

REFERENCES

Chapter 61. THE EFFECT OF IMMUNONEUTRALIZATION OF CRF ON THE GROWTH OF LAMBS

REFERENCES

Chapter 62. EFFECTS OF PASSIVE IMMUNIZATION WITH AN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) MONOCLONAL ANTIBODY (MAB) ON GROWTH AND PITUITARY GROWTH HORMONE (GH) CONTENT INTHE GUINEA PIG

Chapter 63. CONTROL OF GROWTH HORMONE SECRETION DURING GESTATION AND LACTATION IN GILTS ACTIVELY IMMUNIZED AGAINST GROWTH HORMONE-RELEASING FACTOR

REFERENCE

Chapter 64. IMMUNIZATION AGAINST GROWTH HORMONE-RELEASING FACTOR SUPPRESSES IGF-I AND ABOLISHES OPIOID AGONIST INDUCED RELEASE OF GROWTH HORMONE IN LACTATING CATTLE

REFERENCE

Chapter 65. GROWTH HORMONE EXPRESSION AND EFFECTS IN TRANSGENIC SHEEP

REFERENCES

INDEX

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