Front Cover

Progress in Myeloma: Biology of Myeloma

Copyright Page

Table of Contents

Preface

Contributors

Chapter 1. Epidemiology of Multiple Myeloma and Related Plasma Cell Disorders

Introduction

Multiple Myeloma

Waldenström's Macroglobulinemia

Benign Monoclonal Gammopathy (BMG)

Heavy Chain Disease

Chronic Antigenic Stimulation

Conclusions

References

Chapter 2. In Vitro Bone Resorption by Human Myeloma Cells

Introduction

Methods

Clinical Characteristics of the Patients Studied

Results

Discussion

ACKNOWLEDGMENT

References

Chapter 3. Plasma Cell Myeloma and Waldenström's Macroglobulinemia in Black and White South Africans

Summary

Introduction

Patients and Methods

Results

Discussion

References

Chapter 4. In Vivo Pulse Labeling Studies of Murine LPC-1 Plasmacytoma Using 6- 14C-Arginine

Introduction

Materials and Methods

Results

Discussion

References

Chapter 5. Myelomas as Models to Study Activation and Suppression of Normal Lymphocytes

I. Introduction

II. Cellular Events Associated with Immune Induction and Tolerance

III. Membrane Events Associated with B Cell Activation and Tolerance

IV. Membrane Events Associated with the Binding of Immunogenic or Tolerogenic Ligands to Myelomas

V. Inhibition of Myeloma Antibody Production by Antigens

VI. Regulation of Myeloma Growth and Function by Anti-Idiotypic Antibodies

VII. Regulation of Myeloma Growth and Function by T Lymphocytes

VIII. Somatic Cell Hybrids (Hybridomas) A Source of Homogeneous Antigen Reactive B Cells

IX. Summary and Conclusions

References

Chapter 6. Regulation of Murine Myeloma Cell Growth and Differentiation: Cellular and Molecular Mechanisms, and Therapeutic Implications

Introduction

Myeloma Proteins as Tumor-Specific Transplantation Antigens

MOPC-315 Cells Differentiate during In Vivo Growth

MOPC-315 Cells are Antigen-Sensitive

T Cells and Macrophages Mediate Antigen-Specific Regulation of MOPC-315

Antigen-Specific Regulation of Subcutaneous and Disseminated MOPC-315

Neoplastic B Cells as Targets of the Host's Immunoregulatory Apparatus

Summary

ACKNOWLEDGMENT

References

Chapter 7. Characteristics of Multiple Myeloma as an Immunodeficiency Disease

Immunological Defects

References

Chapter 8. Immunodeficiency Induced by Plasma Cell Tumors: Comparison of Findings in Human and Murine Hosts

Summary

Introduction

Measurement of CMI Responses In Vivo

Measurement of Anti-PC Immunity

Measurement of Non-specific Cell-mediated Cytotoxicity

Measurement of Proliferation in Response to Various Mitogens

Conclusions

References

Chapter 9. Myeloma Growth Kinetics: Potential Applications of Flow Cytometry

Introduction

Proliferative Characteristics

Doubling Time Studies

Changes in Labelling Indices After Chemotherapy

Potential Applications of Flow Cytometry to the Study of Myeloma Cell Proliferation

References

Chapter 10. The Extent of Clonal Involvement in Multiple Myeloma

Introduction

Patients

Preparation of Anti-idiotype Antibodies and Their Specificities

Idiotype Expression on Blood Lymphocytes

Serial Studies of Id+B Lymphocytes and Plasma Cells

Idiotype Expression by Pre-B Cells

Discussion

Summary and Conclusions

ACKNOWLEDGMENT

References

Chapter 11. Regulation of the Growth of Myeloma Tumor Cells and Non-Neoplastic B Cell Clones by Antiidiotypic Antibodies

Introduction

Summary

References

Chapter 12. Non-Random Chromosome Changes Involving the Distal End of Chromosome 15 and Chromosomes 6 and 12 in Pristane-Induced Mouse Plasmacytomas

Summary

Materials and Methods

Results

Discussion

ACKNOWLEDGMENTS

References

Chapter 13. A Review of Therapeutic Trials in Multiple Myeloma and Perspectives for Future Trials

Introduction

Definitions

Single Agent Chemotherapy

Combination Chemotherapy

Remission Maintenance

Toxicity and Complications of Cytotoxic Chemotherapy

Future Directions

Conclusions

References

Chapter 14. Genetic Considerations in Plasmacytomas of BALB/c, NZB, and (BALB/c X NZB) F1 Mice

Introduction

Summary

ACKNOWLEDGMENTS

References

Index