Front Cover

Autoimmune Disease Models: A Guidebook

Copyright Page

Table of Contents

Contributors

Preface

Chapter 1. Experimental Autoimmune Encephalomyelitis in the Mouse

I. Introduction: Murine Experimental Autoimmune Encephalomyelitis as a Model for T-CelI-Mediated Demyelinating Disease of the Central Nervous System

II. Models of EAE in the Mouse

III. Evaluation of the Disease

IV. Summary

Acknowledgment

References

Chapter 2. Rat Experimental Autoimmune Encephalomyelitis

I. History and Introduction

II. Animals and Housing

III. Genetic Background

IV. Disease Induction

V. Quantitation

VI. Expert Experience

References

Chapter 3. Theiler's Virus-Induced Demyelinating Disease

I. History and Relevance of the Model

II. The Animals

III. Genetics of Susceptibility or Resistance

IV. The Disease

V. Lessons

References

Chapter 4. Experimental Autoimmune Neuritis

I. Introduction

II. Isolation and Composition of Peripheral Nerve Myelin

III. Basic Features of EAN

IV. Immunopathogenesis of EAN—A Model for Therapeutic Studies

References

Chapter 5. Experimental Autoimmune Uveoretinitis—Rat and Mouse

I. Introduction

II. Rat EAU

III. Mouse EAU

IV. Expert Experience

V. Lessons

References

Chapter 6. Experimental Autoimmune Myasthenia Gravis

I. Introduction

II. Immunization against Purified Electric Organ AChR

III. Assessment of EAMG and the Safety Factor

IV. Immunization against Purified Mammalian AChR

V. Immunization without Adjuvant

VI. Genetics of EAMG in Rats and Mice

VII. T- and B-Cell Epitopes in EAMG

VIII. Immunization against Denatured AChR Subunits, Recombinant or Synthetic Peptides

IX. Resistance to EAMG

X. Alternative Models

XI. Use of EAMG for Therapeutic Studies

XII. Relation to Human Disease

XIII. Conclusions

XIV. Lambert-Eaton Myasthenic Syndrome

References

Chapter 7. The Obese Strain of Chickens with Spontaneous Autoimmune Thyroiditis as a Model for Hashimoto Disease

I. Introduction

II. History and Development of the OS

III. Clinical Symptoms and Pathohistology

IV. Immunological Parameters

V. Breeding and Management of OS Chickens

VI. Immunogenetics

VII. Comparison of SAT and EAT

VIII. Use of the OS for the Development of New Therapeutic Strategies

IX. Conclusions

Acknowledgments

References

Chapter 8. Experimental AutoimmuneThyroiditis in the Mouse and Rat

I. Experimental Autoimmune Thyroiditis in the Mouse

II. Experimental Autoimmune Thyroiditis in the Rat

III. Lessons

Acknowledgments

References

Chapter 9. The NOD Mouse: A Model for Autoimmune Insulin-Dependent Diabetes

I. History of the Model

II. The Animal

III. The Disease

IV. Genetics

V. Treatment and Prevention

VI. Notes for the Beginner

VII. What the Model Has Taught Us about Human IDDM

References

Chapter 10. The BB Rat Models of IDDM

I. History

II. Animals

III. Genetics

IV. The Disease

IV. Quantitation

V. Resistance

VI. Expert Experience

VII. Lessons

References

Chapter 11. Experimental Myocarditis

I. The Models

II. Production of Virus-Induced Myocarditis

III. Production of Myosin-lnduced Myocarditis

IV. Evaluation

Acknowledgment

References

Chapter 12. Experimental Hepatitis

I. History of Experimental Autoimmune Hepatitis

II. Animals

III. Genetic Background

IV. Induction and Time Course

V. Quantitation

VI. Resistance

VII. Expert Experience

VIII. Lessons

References

Chapter 13. Adjuvant Arthritis

I. History of the Model

II. Animals

III. Induction of the Disease

IV. Course of the Disease

V. Quantitation of the Disease

VI. Resistance to the Disease

VII. Expert Experience

VIII. Lessons

Acknowledgment

References

Chapter 14. Murine Models of Spontaneous Systemic Lupus Erythematosus

I. Introduction

II. (NZB x NZW) F

III. MRL-lpr/lpr

IV. Quantitation

V. Conclusions

Acknowledgment

References

Chapter 15. Experimental Systemic Lupus Erythematosus: Role of the Idiotypic Network

I. History of the Model

II. Animals and Housing

III. Genetic Background

IV. Disease Induction

V. Course of the Disease

VI. Resistance to the Disease

VII. Manipulation of the Disease

VIII. Lessons

Acknowledgment

References

Chapter 16. Autoimmune Vasculitis

I. Introduction and History of the Model

II. Animals

III. Genetic Background

IV. Disease Induction

V. Lesion and Course of the Disease

VI. Autoimmune Myositis

References

Chapter 17. Testicular and Ovarian Autoimmune Diseases

I. Introduction

II. Experimental Autoimmune Orchitis

III. Experimental Autoimmune Oophoritis

IV. Autoimmune Oophoritis Following Manipulation of the Normal Murine Immune System

V. Summary and Conclusions

Acknowledgments

References

Chapter 18. Allogeneic Diseases

I. Chronic Graft-versus-Host Disease

II. Host-versus-Graft Disease

III. Lessons

References

Chapter 19. Assessment of Discomfort in Laboratory Animals

I. Introduction

II. Arguments for Assessing Discomfort

III. Stress and Discomfort

IV. Assessment of Discomfort

V. An Example of Assessing Discomfort in Practice

VI. Possibilities for Diminishing Discomfort

References

Index