Description
Recombinant DNA and Genetic Experimentation contains papers from the Proceedings of a Conference on Recombinant DNA held in London on April 1-4, 1979.
This books reviews recombinant DNA research and discusses advances in the application of recombinant DNA research and the regulations affecting such research. Part 1 of the book deals with recombinant DNA techniques that are useful in the biological perspective. These techniques include tests for rare gene exchanger and laboratory genetic manipulations. Part 2 addresses the achievements of recombinant DNA research such as the detection of homologous sequences and progress made in the research of animal viruses. Part 3 discusses the practical benefits of recombinant DNA research, covering topics such as the production of valuable proteins in alternate biological hosts. These proteins are shown as being valuable to society, besides being scientific curiosities.
An important presentation is Part 4 of the symposium, which discusses the guidelines and legislations affecting recombinant DNA research such as prior restraint, prohibitions, risks, and approval of the conduct of such experiments. Part 5 concerns a review of the basic assumptions made in the symposium, while Part 6 tackles the question of what options are left open in the international arena, in the medical field, and in the eyes of the public.
This collection of papers can prove beneficial for molecular biologists, DNA researchers, molecular geneticists, e
Chapter
THE PURPOSE OF THE MEETING
PART 1: RECOMBINANT DNA TECHNIQUES PUT INTO BIOLOGICAL PERSPECTIVE
CHAPTER 1. CHAIRMAN'S INTRODUCTION
CHAPTER 2. EVOLUTION AND STABILITY OF SPECIES
SPECIES AND THEIR FORMATION
RATES OF EVOLUTION AND POLYMORPHISM
CONCLUSIONS AND IMPLICATIONS
CHAPTER 3. ORGANIZATION AND EVOLUTION OF THE EUKARYOTIC GENOME
THE KINETICS OF RENATURATION OF EUKARYOTIC DNA
DENSITY GRADIENT FRACTIONATION OF EUKARYOTIC DNA
CHAPTER 4. NATURAL MODES OF GENETIC EXCHANGE AND CHANGE
IMPORTANCE OF NATURAL GENE TRANSFER
INTERSPECIFIC GENE TRANSFER
ESTABLISHMENT OF TRANSFERRED DNA
BARRIERS TO TRANSFER AND ESTABLISHMENT
TESTS FOR RARE GENE EXCHANGER
CHAPTER 5. TRANSPOSONS AND INSERTION SEQUENCES
CHAPTER 6. LABORATORY GENETIC MANIPULATIONS
PART 2: ACHIEVEMENTS OF RECOMBINANT DNA RESEARCH
CHAPTER 7. EXPERIMENTAL TECHNIQUES AND STRATEGIES FOR DNA CLONING
CHAPTER 8. APPLICATION OF RECOMBINANT DNA TECHNOLOGY TO THE MOLECULAR GENETICS OF PROKARYOTES
DETECTION OF HOMOLOGOUS SEQUENCES
ANALYSIS BY GENETIC RECOMBINATION
GENE FUSIONS AND GENE EXPRESSION
GENE EXPRESSION AND ITS AMPLIFICATION
CHAPTER 9. NEW INSIGHTS INTO THE MOLECULAR GENETICS OF ANIMALS
GENE REARRANGEMENTS AND IMMUNOGLOBULIN GENES
POSSIBLE TRANSCRIPTIONAL CONTROL REGIONS
CHAPTER 10. RECOMBINANT DNA AND ANIMAL VIRUSES: PROGRESS AND PROSPECTS
CHAPTER 11. CHAIRMAN'S INTRODUCTION
CHAPTER 12. NEW INSIGHTS INTO THE MOLECULAR GENETICS OF FUNGI AND PLANTS
MOLECULAR GENETICS OF PLANTS
CHAPTER 13. RECOMBINANT DNA AND AGRICULTURAL RESEARCH
CHAPTER 14. EXPRESSION OF FOREIGN GENES
BARRIERS TO HETEROSPECIFIC GENE EXPRESSION
HETEROSPECIFIC REPLICATION
PART 3: PRACTICAL BENEFITS OF RECOMBINANT DNARESEARCH
CHAPTER 15. CHAIRMAN'S INTRODUCTION
CHAPTER 16. PRODUCTION OF 'VALUABLE" PROTEINS IN ALTERNATE BIOLOGICAL HOSTS
CHAPTER 17. THE EXPRESSION OF A CLONED RABBIT CHROMOSOMAL ß-GLOBIN GENE IN MOUSE L CELLS AND YEAST
TRANSFORMATION OF MOUSE L CELLS WITH RABBIT β-GLOBIN DNA
IDENTIFICATION AND CHARACTERIZATION OF RABBIT β-GLOBIN SPECIFIC TRANSCRIPTS FROM TRANSFORMED MOUSE L CELLS
TRANSFORMATION OF YEAST WITH CLONED RABBIT CHROMOSOMAL ß-GLOBIN DNA
CHARACTERIZATION OF β-GLOBIN-SPECIFIC TRANSCRIPTS IN YEAST
PART 4: GUIDELINES AND LEGISLATION
CHAPTER 18. CHAIRMAN'S INTRODUCTION
CHAPTER 19. A HISTORY OF THE RECOMBINANT DNA GUIDELINES IN THE UNITED STATES
THE END O F THE BEGINNING
ISSUANCE OF THE GUIDELINES
EXTENSION OF THE GUIDELINES BEYOND NIH
ΝΕΡΑ AND THE FRIENDS OF THE EARTH
THRUSTS TOWARD LEGISLATION
CHAPTER 20. THE EARLY HISTORY OF THE RECOMBINANT DNA MOLECULE PROGRAM ADVISORY COMMITTEE OF NIH
RECOMBINANT DNA MOLECULE PROGRAM ADVISORY COMIITTEE AND TERMS OF MEMBERSHIP
CHAPTER 21. HOW THE NIH RECOMBINANT DNA MOLECULE COMMITTEE WORKS IN 1979
CHAPTER 22. GUIDELINES, LEGISLATION AND LABOUR RELATIONS
CHAPTER 23. RECOMBINANT DNA GUIDELINES AND LEGISLATION
CHAPTER 24. SUMMARY OF REPORT TO COGENE OF THE WORKING GROUP ON RECOMBINANT DNA GUIDELINES
PART 5: RE-EXAMINATION OF BASIC ASSUMPTIONS
CHAPTER 25. CHAIRMAN'S INTRODUCTION
CHAPTER 26. WHY THE "BERG" LETTER WAS WRITTEN
CHAPTER 27. BIOLOGICAL ACTIVITY OF POLYOMA-PLASMID AND POLYOMA-PHAGE RECOMBINANTS IN MICE AND HAMSTERS
CHAPTER 28. INFECTIVITY OF POLYOMA VIRUS-PLASMID pBR322 AND POLYOMA VIRUS-LAMBDA RECOMBINANTS IN MOUSE FIBROBLASTS
CHAPTER 29. SECOND REPORT OF THE COGENE WORKING GROUP ON RISK ASSESSMENT
APPENDIX I: REPORT ON THE PHAGE AND PLASMID SUBCOMMITTEE ON
MEETING WITH RECOMBINANT DNA CONTRACTORS
CONCLUSIONS OF THE PHAGE AND PLASMID SUBCOMMITTEE CONCERNING THE CONTRACTORS' REPORTS
APPENDIX II: SUMMARY OF CONCLUSIONS FROM FEEDING AND MONITORING EXPERIMENTS2
CHAPTER 30. WHAT LESSONS DOES THE RECOMBINANT DNA DEBATE TEACH US A ROUND TABLE DISCUSSION
PART 6: WHAT OPTIONS ARE NOW OPEN?
CHAPTER 31. CHAIRMAN'S INTRODUCTION
CHAPTER 32. INTERNATIONAL LEGAL ASPECTS OF RECOMBINANT DNA RESEARCH
2. National Occupational and Environmental Hazards
4. The Institutional Framework
BIOLOGY IN INTERNATIONAL LAW
CHAPTER 33. RECOMBINANT DNA: A PUBLIC HEALTH VIEWPOINT
CHPATER 34. THE VIEW OF A SCIENCE JOURNALIST
CHPATER 35. HISTORICAL PERSPECTIVES ON THE RECOMBINANT DNA CONTROVERSY
CHAPTER 36. THE PUBLIC PERCEPTION OF RISK
CHAPTER 37. THE VIEW OF A LEGISLATER AND A SUMMARY OF THE CONFERENCE
Recombinant DNA and Genetic Experimentation
：Proceedings of a Conference on Recombinant DNA, Jointly Organised by the Committee on Genetic Experimentation (COGENE) and the Royal Society of London, Held at Wye College, Kent, UK, 1-4 April, 1979
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
