Drugs, Addiction, and the Brain

Author: Koob   George F.;Arends   Michael A.;Moal   Michel Le  

Publisher: Elsevier Science‎

Publication year: 2014

E-ISBN: 9780123869593

P-ISBN(Paperback): 9780123869371

P-ISBN(Hardback):  9780123869371

Subject: R74 Neurology and Psychiatry;R741 Neurology;R9 Pharmacy

Language: ENG

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Description

Drugs, Addiction, and the Brain explores the molecular, cellular, and neurocircuitry systems in the brain that are responsible for drug addiction. Common neurobiological elements are emphasized that provide novel insights into how the brain mediates the acute rewarding effects of drugs of abuse and how it changes during the transition from initial drug use to compulsive drug use and addiction. The book provides a detailed overview of the pathophysiology of the disease. The information provided will be useful for neuroscientists in the field of addiction, drug abuse treatment providers, and undergraduate and postgraduate students who are interested in learning the diverse effects of drugs of abuse on the brain.

  • Full-color circuitry diagrams of brain regions implicated in each stage of the addiction cycle
  • Actual data figures from original sources illustrating key concepts and findings
  • Introduction to basic neuropharmacology terms and concepts
  • Introduction to numerous animal models used to study diverse aspects of drug use.
  • Thorough review of extant work on the neurobiology of addiction

Chapter

NEUROADAPTATIONAL VIEWS OF ADDICTION

SUMMARY

Suggested Reading

Chapter 2 - Introduction to the Neuropsychopharmacology of Drug Addiction

THE CENTRAL NERVOUS SYSTEM

PHARMACOLOGY FOR ADDICTION

PHARMACOKINETICS

BASIC NEUROBIOLOGY OF ADDICTION

BRAIN STRUCTURES AND FUNCTIONS RELEVANT TO THE THREE STAGES OF THE ADDICTION CYCLE

NEUROADAPTATIONAL SUMMARY

Suggested Reading

Chapter 3 - Animal Models of Addiction

VALIDATION OF ANIMAL MODELS OF DRUG ADDICTION

ANIMAL MODELS OF THE BINGE/INTOXICATION STAGE OF THE ADDICTION CYCLE

ANIMAL MODELS OF THE WITHDRAWAL/NEGATIVE AFFECT STAGE OF THE ADDICTION CYCLE

ANIMAL MODELS OF THE PREOCCUPATION/ANTICIPATION STAGE OF THE ADDICTION CYCLE

ANIMAL MODELS OF VULNERABILITY TO ADDICTION

SUMMARY OF ANIMAL MODELS OF ADDICTION

Suggested Reading

Chapter 4 - Psychostimulants

DEFINITIONS

HISTORY OF PSYCHOSTIMULANT USE

PHYSIOLOGICAL EFFECTS

BEHAVIORAL EFFECTS

MEDICAL USES

PHARMACOKINETICS

BEHAVIORAL MECHANISM OF ACTION

USE, ABUSE, AND ADDICTION

NEUROBIOLOGICAL EFFECTS

SUMMARY

Suggested Reading

Chapter 5 - Opioids

DEFINITIONS

HISTORY OF OPIOID USE

PHYSIOLOGICAL EFFECTS

BEHAVIORAL EFFECTS

MEDICAL USES

PHARMACOKINETICS

BEHAVIORAL MECHANISM

USE, ABUSE, AND ADDICTION

NEUROBIOLOGICAL EFFECTS

SUMMARY

Suggested Reading

Chapter 6 - Alcohol

DEFINITIONS

HISTORY OF ALCOHOL USE

BEHAVIORAL EFFECTS

PHARMACOKINETICS

USE, ABUSE, AND ADDICTION

ALCOHOL TOXICITY

BEHAVIORAL MECHANISM OF ACTION

NEUROBIOLOGICAL EFFECTS

SUMMARY

Suggested Reading

Chapter 7 - Nicotine

DEFINITIONS

HISTORY OF USE

MEDICAL USE AND BEHAVIORAL EFFECTS

PHARMACOKINETICS

USE, ABUSE, AND ADDICTION

BEHAVIORAL MECHANISM

NEUROBIOLOGICAL EFFECTS

SUMMARY

Suggested Reading

Chapter 8 - Cannabinoids

DEFINITIONS

HISTORY OF CANNABINOID USE

MEDICAL USES

BEHAVIORAL EFFECTS

PHARMACOKINETICS

USE, ABUSE, AND ADDICTION

BEHAVIORAL MECHANISM OF ACTION

NEUROBIOLOGICAL EFFECTS

SUMMARY

Suggested Reading

Chapter 9 - Medications for the Treatment of Addiction – A Neurobiological Perspective

CONCEPTUAL APPROACH FOR UNDERSTANDING CURRENT AND FUTURE MEDICATIONS DEVELOPMENT

EFFECTS OF KNOWN MEDICATIONS ON ANIMAL MODELS OF ADDICTION – REVERSE VALIDITY (ROSETTA STONE APPROACH)

NOVEL TARGETS FOR MEDICATION DEVELOPMENT

HUMAN LABORATORY STUDIES

INDIVIDUAL DIFFERENCES AND MEDICATION DEVELOPMENT

CLINICAL TRIALS – UNIQUE

SUMMARY

Suggested Reading

Index

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