Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses :Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27-29, 1981

Publication subTitle :Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27-29, 1981

Author: Lechat   P.;Thesleff   S.;Bowman   W. C.  

Publisher: Elsevier Science‎

Publication year: 2013

E-ISBN: 9781483150437

P-ISBN(Paperback): 9780080280004

P-ISBN(Hardback):  9780080280004

Subject: R9 Pharmacy

Language: ENG

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Description

Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses presents the proceedings of a IUPHAR Satellite Symposium in conjunction with the eighth International Congress of Pharmacology held in Paris, France on July 27-29, 1981. The book contains papers on the effects of aminopyridines on ionic currents in excitable membranes; the effects of aminopyridines on synaptic transmission; and the effects of aminopyridines on the release of chemical transmitters. The text also presents papers on some differences in the blockade of potassium permeabilities by apamin and the aminopyridines; the miscellaneous actions of aminopyridines and related compounds; and the effects of aminopyridines on the skeletal, smooth and cardiac muscle. The clinical applications of aminopyridines and further miscellaneous actions of aminopyridines and related compounds are also considered.

Chapter

Historical Review

Part 1: Aminopyridines and Ionic Currents in Excitable Membranes

Chapter 1. General Review on Potassium Currents in Excitable Membranes of Nerve and Muscle

ABSTRACT

KEYWORDS

TIME COURSE OF POTASSIUM CURRENTS

DIAMETER AND CONDUCTANCE OF SINGLE POTASSIUM CHANNELS

PECULIARITIES OF THE Κ PERMEABILITY IN CERTAIN TISSUES

BLOCK OF Κ CHANNELS

REFERENCES

Chapter 2. Effects of Aminopyridines on Potassium Currents of the Nodal Membrane

ABSTRACT

KEYWORDS

INTRODUCTION

METHODS

RESULTS

DISCUSSION

ACKNOWLEDGEMENTS

REFERENCES

Chapter 3. Properties and Physiological Roles of Κ + Currents in Frog Myelinated Nerve Fibres as Revealed by 4-Amino Pyridine

ABSTRACT

KEYWORDS

INTRODUCTION

METHODS

RESULTS

CONCLUSION

ACKNOWLEDGEMENT

REFERENCES

Chapter 4. Effects of Aminopyridines on Ionic Currents and Ionic Channel Noise in Unmyelinated Axons

ABSTRACT

KEYWORDS

INTRODUCTION

METHODS

RESULTS

DISCUSSION

ACKNOWLEDQIENTS

REFERENCES

Chapter 5. 3- and 4-Aminopyridine in Synaptic Transmission at the Squid Giant Synapse

ABSTRACT

KEYWORDS

TECHNIQUES

RESULTS

CONCLUSIONS

ACKNOWLEDGEMENT

REFERENCES

Part 2: Aminopyridines and Synaptic Transmission

Chapter 6. General Principles of Synaptic Transmission

ABSTRACT

KEYWORDS

REFERENCES

Chapter 7. Effects of Aminopyridines on Neuromuscular Transmission

ABSTRACT

KEYWORDS

INTRODUCTION

AMINOPYRIDINES ON VERTEBRATE NEUROMUSCULAR JUNCTIONS

AMINOPYRIDINES ON INVERTEBRATE NEUROMUSCULAR JUNCTIONS

MECHANISM OF ACTION

ACKNOWLEDGEMENTS

REFERENCES

Chapter 8. Effects of 4-Aminopyridine on Transmission in Excitatory and Inhibitory Synapses in the Spinal Cord

ABSTRACT

KEYWORDS

INTRODUCTION

DOSAGE AND TIME COURSE OF EFFECTS OF 4-AP

EFFECTS OF 4-AP ON INHIBITORY PATHWAYS

CONTROL TESTS ON THE SITE OF ACTION OF 4-AP

COMMENTS ON THE USE OF 4-AP FOR CLINICAL PURPOSES AND IN STUDIES OF THE CENTRAL NERVOUS SYSTEM

ACKNOWLEDGEMENT

REFERENCES

Chapter 9. The Influence of 4-Aminopyridine on Parasympathetic Transmission

ABSTRACT

KEYWORDS

INTRODUCTION

METHODS

RESULTS

DISCUSSION

REFERENCES

Part 3: Aminopyridines and the Release of Chemical Transmitters: Contrast with Apamin

Chapter 10. Structure - Activity Relationships Amongst Aminopyridines

ABSTRACT

KEYWORDS

INTRODUCTION

ACTIONS ON ELECTRICALLY EXCITABLE MEMBRANES

ACTIONS ON THE CENTRAL NERVOUS SYSTEM

EPPECTS ON NEUROMUSCULAR TRANSMISSION

EFFECTS ON PARASYMPATHETIC NEUROEFFECTOR TRANSMISSION

EFFECTS ON SYMPATHETIC NEUROEFFECTOR TRANSMISSION

EFFECTS ON CARDIAC MUSCLE

PRESENT AND POTENTIAL CLINICAL USES OF AMINOPYRIDINES

ACKNOWLEDGEMENT

REFERENCES

Chapter 11. Aminopyridine as a Tool to Investigate the Mechanism of Acetylcholine Release at the Nerve Electroplaque Junction

ABSTRACT

KEYWORDS

INTRODUCTION

METHODS

RESULTS AND DISCUSSION

CONCLUSION

ACKNOWLEDGEMENTS

REFERENCES

Chapter 12. Intramembrane Particles Changes: A Constant Feature of the Release Mechanism

ABSTRACT

KEYWORDS

INTRODUCTION

PRESYNAPTIC MEMBRANE MODIFICATIONS IN THE COURSE OF ACh RELEASE

SYNAPTOSOMAL ACh CONTENT AND COMPARTMENTATION

CONTINUOUS DETERMINATION OF ACh RELEASE

THE MECHANISM OF ACh RELEASE

REFERENCES

Chapter 13. Effect of Aminopyridine and Related Drugs on Catecholamine Release

ABSTRACT

KEYWORDS

INTRODUCTION

METHODS

RESULTS

DISCUSSION

REFERENCES

Chapter 14. Some Differences in the Blockade of Potassium Permeabilities by Apamin and the Aminopyridines

ABSTRACT

KEYWORDS

INTRODUCTION

PERIPHERAL ACTIONS OF APAMIN

APAMIN IN RELATION TO THE AMINOPYRIDINES

FINAL COMMENTS

REFERENCES

Part 4: Miscellaneous Actions of Aminopyridines and Related Compounds: Poster Commimications

Chapter 15. The Action of Morphine Dependence on the Convulsive Effect of 4-Aminopyri and Other Drugs

Chapter 16. Antagonism to Dopaminergic Stereotypy, and Convulsant and Hypertensive Effects by 2-Amino-4-Methylpyridine

Chapter 17. 4-Aminopyridine (4AP) Enhances Acetylcholine Output from the Rat Cerebral Cortex in vivo

Chapter 18. 4-Aminopyridine as a Tool to Elucidate Different Actions of Botulinum A and Tetanus Toxin at the Mouse Neuromuscular Junction

Chapter 19. Antagonism of the Myoneural Activity of Antibiotics, Local Anesthetics and General Anesthetics By 4-APYR

Chapter 20. Increased Tetanic Fade Produced by 3,4-Diaminopyridine in the Presence of Neuromuscular Blocking Agents

Chapter 21. Effect of 4-Aminopyridine on the Electrical Activity of the Hippocampus and the Cerebellum

Chapter 22. Cardiac Effects of 4-Aminoquinoline on Mammalian and Amphibian Isolated Preparations An Electrophysiological Study

Chapter 23. Facilitatory Effects of Aminopyridines on Synaptic Transmission in the Sixth Abdominal Ganglion of the Cockroach

Chapter 24. The Effect of 3-,4-AP and 3,4-DAP on the Evoked Activity of the Pyramidal Cell Layer (CA 1,2) of the Hippocampus An in vitro Study

Chapter 25. Fast and Slow Automatic Activity of Squid Giant Axons Induced by 4-Aminopyridine

Chapter 26. The Ability of 4-Aminopyridine and 3,4-Diaminopyridine to Gross the Blood-Brain Barrier can Account for Their Difference in Toxicity

Chapter 27. Action of 4AP and TEA on Presynaptic Currents in Mammalian Motor Endings

Chapter 28. Protein Synthesis in Brain Subcellular Fractions Effect of 4-Amino-Pyridine

Chapter 29. Effects of 4-Hydroxypyridine on Transmitter Release at the Neuromuscular Junction

Chapter 30. 4-Aminopyridine Analogs of Novel Chemical Structure

Chapter 31. Excitatory Action of Imidazole on Evoked Transmitter Release from the Phrenic Nerve and on Potassium-stimulated 45Ca Uptake by Synaptosomes in the Rat

Chapter 32. Aminopyridine Effects on Molecular Models in Myopathic States

Chapter 33. Effects of Pyridine on the Frog Rectus Abdominis Muscle

Chapter 34. 4-Aminopyridine and Pre-synaptic Modulation of Transmitter Release in Aplysia

Chapter 35. Naloxone, 4-Aminopyridine and Physostigmine as Antagonists of Morphine in Rabbits

Chapter 36. Anti-Curare Action of 4-Aminopyridine and 4-Aminopyridine-like Substances

Chapter 37. 4-Aminopyridine Reversal of Morphine Analgesia

Chapter 38. 4-Aminopyridine as Antagonist of the Cardio vascular and Neuromuscular Depressant Effects of Kanamycin in Rats

Chapter 39. Further Actions of Aminopyridines on Muscle and Nerve: Short Communications

Chapter 40. Effects of 4-Aminopyridine on Mammalian Peripheral and Central Neurones

Chapter 41. Interactions of Aminopyridines and Related Compounds with Ionic Channels in the Isolated Cockroach Axon

Chapter 42. 4-Aminopyridine-induced Alteration in the Receptive Field of Cuneate and Gracile Neurones

Chapter 43. Effect of 4-Aminopyridine on the Desensitisation of the Rat Diaphragm Caused by Carbachol

Chapter 44. The Effects of 4-Aminopyridine on Neuromuscular Block Produced by Succinyldicholine

Chapter 45. Chemical Modulators: Their Molecular Characteristics and Kinetics of Actions

Part 5: Aminopyridines and Skeletal, Smooth and Cardiac Muscle

Chapter 46. Effects of 4-Aminopyridine on Contractile Properties of Skeletal Muscle

ABSTRACT

KEYWORDS

INTRODUCTION

METHODS

RESULTS AND DISCUSSION

ACKNOWLEDGEMENT

REFERENCES

Chapter 47. Effects of 4-Aminopyridine on Cardiac Muscle

ABSTRACT

KEYWORDS

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

REFERENCES

Chapter 48. Effects of 4-Aminopyridine on Isometric Force [Ca++] Relations in Mammalian Slow and Fast Twitch Skinned Muscle Fibres

Chapter 49. 4-Aminopyridine and Outward Membrane Currents in Rat Uterine Smooth Muscle at Various Stages of Pregnancy

Chapter 50. Effects of 4-Aminopyridine on Membrane Currents in the Pace-maker Voltage Range of Sheep Cardiac Purkinje Fibres

Chapter 51. Is the Cardiotonic Effect of Aminopyridines and Aminopyrimidines in vitro A Consequence of Increased Extracellular pH?

Part 6: Clinical Applications of Aminopyridines

Chapter 52. Therapeutic Applications of Aminopyridines in Diseases of Neuromuscular Transmission

ABSTRACT

KEYWORDS

INTRODUCTION

METHODS

EFFECTS IN VITRO ON INTERCOSTAL MUSCLE

EFFECTS IN VIVO IN EATON-LAMBERT SYNDROME

EFFECTS IN VIVO IN MYASTHENIA GRAVIS

PHARMACOKINETICS

CLINICAL SIDE EFFECTS

DISCUSSION

ACKNOWLEDGEMENTS

REFERENCES

Chapter 53. Use of 4-Ammopyridine in Human Botulism

ABSTRACT

KEYWORDS

INTRODUCTION

PATIENTS AND METHODS

RESULTS OF SINGLE AND DOUBLE DOSE ADMINISTRATION OF 4-AP

CONCLUSIONS

ACKNOWLEDGEMENT

REFERENCES

Chapter 54. Therapeutic Applications of 4-Aminopyridine in Anaesthesia

ABSTRACT

KEYWORDS

INTRODUCTION

NEUROMUSCULAR JUNCTION

CENTRAL NERVOUS SYSTEM (CNS)

PHARMACOKINETICS

SUMMARY AND CONCLUSIONS

ACKNOWLEDGEMENT

REFERENCES

Chapter 55. Effects of 3,4-Diaminopyridine in Cynomolgus Monkeys Poisoned with Type A Botulinum Toxin

Part 7: Further Miscellaneous Actions of Aminopyridines and Related Compounds Short Communications

Chapter 56. Potassium Channel Block by S-Methylthiouronium, A Pharmacological Analogue of 4-Aminopyridine

Chapter 57. Differences in Actions of 4-Aminopyridine and 4-Methyl-2-Aminopyridine

Chapter 58. Effects of Aminopyridines in Avian Muscular Dystrophy

Chapter 59. Comparison of the Actions of Dendrotoxin, A Facihtatory Neurotoxin, and 3,4-Diaminopyridine on Neuromuscular Transmission

Chapter 60. Effects of Aminopyridines on Parasympathetic Neuro-effector Transmission in the Heart

Chapter 61. Effects of 4-Aminopyridine on Endocrine Cells

Chapter 62. An Electroencephalographic Study of 4-Aminopyridine in Conscious Volunteers

Conclusions

Index

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