Publisher： Bentham Science Publishers
E-ISSN： 1875-5607|7|12|1186-1205
ISSN： 1389-5575
Source： Mini Reviews in Medicinal Chemistry, Vol.7, Iss.12, 2007-12, pp. : 1186-1205
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Abstract
Combretastatin A-4 (CA-4) is one of the most potent antimitotic and antiangiogenic agents of natural origin. It has displayed potent antitumor effect in a wide variety of preclinical tumor models. Till date various CA-4 analogs have been synthesized and evaluated for anticancer activity. This review is an attempt to compile the medicinal chemistry of various synthesized CA-4 analogs.
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