Piperlongumine attenuates collagen-induced arthritis via expansion of myeloid-derived suppressor cells and inhibition of the activation of fibroblast-like synoviocytes

Author：

Publisher： Spandidos Publications

E-ISSN： 1791-3004|11|4|2689-2694

ISSN： 1791-2997

Source： Molecular Medicine Reports, Vol.11, Iss.4, 2015-01, pp. : 2689-2694

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Abstract

Piperlonguminine (PL), a key compound from the Piper longum fruit, is known to exhibit antitumor and antiinflammatory activities. However, little is known about its effects on collageninduced arthritis (CIA). Fibroblastlike synoviocytes (FLS) have a pivotal role in the development of rheumatoid arthritis (RA). Myeloidderived suppressor cells (MDSCs) are able to suppress T cell responses and have important roles in the regulation of autoimmune arthritis. The current study investigated whether PL alters the progression of RA. It was determined that PL reduces the arthritis score and histopathologic lesions in a mouse model of CIA. PL also reduces the expression levels of serum anticollagen II antibodies (antiC), tumor necrosis factorα (TNFα), interleukin (IL)1β, IL23 and IL17 in CIA mice. In draining lymph nodes (DLNs), MDSCs were significantly expanded, however, the number of Th17 cells was markedly decreased by PL treatment. Additionally, PL reduced secretion of IL1β, IL23 and IL17 by TNFαstimulated human RA FLS. PL significantly inhibited the migration and invasion of TNFαstimulated human RA FLS. These results indicate that PL may be a candidate therapeutic agent for the treatment of RA, via the expansion of MDSCs and the inhibition of the Th17 response and activation of FLS.