Publisher： Spandidos Publications
E-ISSN： 1792-1082|9|4|1971-1975
ISSN： 1792-1074
Source： Oncology Letters, Vol.9, Iss.4, 2015-01, pp. : 1971-1975
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Abstract
MicroRNAs (miRNAs) are a class of small noncoding RNA molecules that serve an important function in carcinogenesis and tumor progression. The present study investigated the roles and mechanisms of miRNA125b (miR125b) in human hepatocellular carcinoma (HCC). miR125b was significantly downregulated in the examined HCC tissues and cell lines. Overexpression of miR125b reduced HCC cell migration and invasion. By contrast, inhibition of miR125b expression significantly accelerated HCC cell migration and invasion. In addition, the present study identified transcriptional coactivator with PDZbinding motif (TAZ) as a functional downstream target of miR125b. Furthermore, overexpression of TAZ impaired miR125binduced inhibition of invasion in HCC cells. The current study demonstrated that miR125b may be involved in the tumorigenesis of HCC at least in part by the suppression of TAZ.
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