Publisher： Spandidos Publications
E-ISSN： 1792-1082|9|5|2090-2094
ISSN： 1792-1074
Source： Oncology Letters, Vol.9, Iss.5, 2015-01, pp. : 2090-2094
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Abstract
The purpose of the present study was to investigate the expression of TAp73 and ∆Np73 in cervical squamous cancer cells, and to evaluate the prognostic significance of TAp73 and ∆Np73 expression in patients with International Federation of Gynecology and Obstetrics (FIGO) stage III cervical squamous cell carcinoma (SCC). The immunohistochemical expression of TAp73 and ∆Np73 was evaluated in 59 FIGO stage III cervical SCC tumor samples. Correlations with clinicopathological characteristics were determined by χ2 test. The prognostic impact of TAp73 and ∆Np73 expression with regard to overall survival (OS) was determined by the KaplanMeier method. High TAp73 and ∆Np73 expression was detected in 79.7% (47/59) and 76.3% (45/59) of patients, respectively. The expression of TAp73 and ∆Np73 was not associated with age, FIGO stage, pathological differentiation or lymph node metastasis. The 3year OS rates associated with low and high TAp73 expression were 75.0 and 83.0%, respectively (χ2=0.33; P=0.568), whereas those associated with low and high ∆Np73 expression were 100.0 and 75.6%, respectively (χ2=3.90; P=0.048). High expression levels of TAp73 and ∆Np73 were frequently observed in the cervical squamous cancer cells. Overall, high expression levels of ∆Np73 may indicate an unfavorable prognosis in patients with earlystage cervical SCC.
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