Publisher： Bentham Science Publishers
E-ISSN： 1873-4294|7|2|135-145
ISSN： 1568-0266
Source： Current Topics in Medicinal Chemistry, Vol.7, Iss.2, 2007-01, pp. : 135-145
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Abstract
The 1 adrenoceptors are three of nine well-characterized receptors that are activated by epinephrine and norepinephrine. Agonists acting at the 1 adrenoceptors produce numerous physiological effects, and are used therapeutically for several indications. Many known 1 adrenoceptor agonists are 1A selective, but the discovery of highly selective 1B and 1D adrenoceptor agonists has proven to be an extremely difficult goal to achieve. This review will focus on recent advances in the discovery, development and clinical utility of subtype-specific 1 agonists as well as contributions to our understanding of agonist-receptor interactions.
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