First Inhibitors of the Steroidogenic Enzyme Type 7 17&bgr;-Hydroxysteroid Dehydrogenase

Publisher： Bentham Science Publishers

E-ISSN： 1875-628x|1|3|194-197

ISSN： 1570-1808

Source： Letters in Drug Design & Discovery, Vol.1, Iss.3, 2004-07, pp. : 194-197

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Abstract

We present the SAR study that led us to identification of the first inhibitors of type 7 17&bgr;- hydroxysteroid dehydrogenase (17&bgr;-HSD). The conversion of E1 into E2 is reduced by nearly 90 % by 17&bgr;-(Nalkylformamido)- 4-methyl-4-aza-5&agr;-androstan-3-one compounds bearing a side chain containing 7 to 10 carbon atoms when tested at 0.3 &mgr;M.

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