First Inhibitors of the Steroidogenic Enzyme Type 7 17&bgr;-Hydroxysteroid Dehydrogenase

Publisher: Bentham Science Publishers

E-ISSN: 1875-628x|1|3|194-197

ISSN: 1570-1808

Source: Letters in Drug Design & Discovery, Vol.1, Iss.3, 2004-07, pp. : 194-197

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

We present the SAR study that led us to identification of the first inhibitors of type 7 17&bgr;- hydroxysteroid dehydrogenase (17&bgr;-HSD). The conversion of E1 into E2 is reduced by nearly 90 % by 17&bgr;-(Nalkylformamido)- 4-methyl-4-aza-5&agr;-androstan-3-one compounds bearing a side chain containing 7 to 10 carbon atoms when tested at 0.3 &mgr;M.