Advanced Pharmacophore Model of Non-Competitive AMPA Antagonist 2,3-benzodiazepines

Publisher: Bentham Science Publishers

E-ISSN: 1875-628x|1|3|217-223

ISSN: 1570-1808

Source: Letters in Drug Design & Discovery, Vol.1, Iss.3, 2004-07, pp. : 217-223

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Abstract

Detailed SAR examination and DIStance COmparison (DISCO) computation were used for identification and superposition of common structural features of 2,3-benzodiazepines with high affinity to an allosteric AMPA binding site. Two similar 4-point models were identified; both contained 2 donor sites, a donor atom and a hydrophobic centre. At one of the donor sites a characteristic difference between the two models was observed.