Publisher： Bentham Science Publishers
E-ISSN： 1875-533x|19|2|292-297
ISSN： 0929-8673
Source： Current Medicinal Chemistry, Vol.19, Iss.2, 2012-01, pp. : 292-297
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Utilizing the intrinsic optical signal (IOS) of retinal Spreading Depression (rSD) waves and the concomitant transparency changes of the tissue, we show that nicotine, in an in vivo near tissue preparation, has neuroprotective effects against the excitotoxic cell death, mediated through the activation of glutamate-receptors. For this study the retinal tissue was treated with NMDA, an agonist for the NMDA-glutamate-receptor, being excitotoxic at higher concentrations, to induce tissue damage. The protective effects of nicotine against glutamate induced neurotoxicity are demonstrated, comparing the IOS with NMDA and NMDA + nicotine. We additionally present data about the decrease of the propagation velocity of rSD waves after nicotine application and show analogical effects obtained with epibatidine, a specific nicotinic acetylcholine receptor (nAChR) agonist.
Related content
Lithium has neuroprotective properties
Inpharma, Vol. 1, Iss. 1393, 2003-01 ,pp. :
Access to resources
Recommend
Neuropharmacology of the Interoceptive Stimulus Properties of Nicotine
Current Drug Abuse Reviews, Vol. 2, Iss. 3, 2009-09 ,pp. :