Molecular Determinants of Fluoroquinolone Antibacterial Agents Pharmacokinetics

Publisher: Bentham Science Publishers

E-ISSN: 2212-3938|4|3|191-197

ISSN: 1574-8847

Source: Current Clinical Pharmacology, Vol.4, Iss.3, 2009-09, pp. : 191-197

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Abstract

This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.