Publisher： Bentham Science Publishers
E-ISSN： 1875-6638|8|4|569-586
ISSN： 1573-4064
Source： Medicinal Chemistry, Vol.8, Iss.4, 2012-07, pp. : 569-586
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The synthesis of 4-(1-adamantyl)-4,4-diarylbutylamines 1, 5-(1-adamantyl)-5,5-diarylpentylamines 2 and 6-(1-adamantyl)-6,6-diarylhexylamines 3 is described and the σ1, σ2-receptors and sodium channels binding affinity of compounds 1 were investigated. The in vitro activity of compounds 1, 2 and 3 against main cancer cell lines is significant. One of the most active analogs, 1a, had an interesting in vivo anticancer profile against the ovarian cancer cell line IGROV-1, which was associated with an anagelsic activity against the neuropathic pain induced by the main anticancer drugs.
Related content
New Cysteine Derivatives with Antiproliferative Activity on Melanoma Cells
Medicinal Chemistry, Vol. 2, Iss. 2, 2006-03 ,pp. :
Access to resources
Recommend
By Piruzyan L. A. Kabankin A. S. Gabrielyan L. I. Ostapchuk N. V. Pyn'ko N. E. Radkevich L. A.
Pharmaceutical Chemistry Journal, Vol. 38, Iss. 3, 2004-03 ,pp. :