Publisher： Bentham Science Publishers
E-ISSN： 1875-5402|15|6|503-508
ISSN： 1386-2073
Source： Combinatorial Chemistry & High Throughput Screening, Vol.15, Iss.6, 2012-07, pp. : 503-508
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Abstract
An efficient synthesis of dialkyl pyrrolo[2,1-a]isoquinoline-2,3-dicarboxylates, pyrrolo[1,2-a]quinoline-1,2- dicarboxylates and indolizines is described via one-pot reactions of isoquinoline, quinoline or pyridine and phenacyl bromids with dialkyl acetylenedicarboxylates or diaryloylacetylene under solvent-free conditions at 50°C. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.
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