Synthesis of Unsaturated 5-Acyloxybenzothiazoleamides via the Passerini Three-Component Reaction

E-ISSN： 1875-5402|16|9|726-730

ISSN： 1386-2073

Source： Combinatorial Chemistry & High Throughput Screening, Vol.16, Iss.9, 2013-11, pp. : 726-730

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Abstract

4-Benzothiazol-2-ylamino-4-oxo-2-butenoic acid, prepared from reaction of 2-aminobenzothiazole and maleic anhydride, are used as an acid component in Passerini three-component reaction, under solvent-free media, to produce unsaturated -benzothiazole acyloxyamides in good yields.

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