Recognition of Single Stranded and Double Stranded DNA/RNA Sequences in Aqueous Medium by Small Bis-Aromatic Derivatives

Publisher: Bentham Science Publishers

E-ISSN: 1875-5607|10|4|299-308

ISSN: 1389-5575

Source: Mini Reviews in Medicinal Chemistry, Vol.10, Iss.4, 2010-04, pp. : 299-308

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Abstract

The aim of this review is to summarize the most comprehensive results in the field of bis-aromatic compounds targeting DNA and RNA, whereby both aromatic units of small molecule bind to the polynucleotide by the aromatic stacking interactions. The most recent results about structure - DNA/RNA binding affinity, selectivity and biological implications are discussed for bis-intercalators, sterically restricted macrocyclic and threading bis-aromatics and intercalator - nucleobase conjugates.