DNA-binding Antitumor Agents: from Pyrimido[5,6,1-de]acridines to Other Intriguing Classes of Acridine Derivatives

Publisher: Bentham Science Publishers

E-ISSN: 1875-533x|9|18|1701-1716

ISSN: 0929-8673

Source: Current Medicinal Chemistry, Vol.9, Iss.18, 2002-09, pp. : 1701-1716

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Abstract

In the field of antitumor DNA-binding agents, the class of acridine derivatives play an important role either as number of compounds or as importance of their anticancer properties. We have synthesized a number of acridine derivatives as potential antitumor drugs, in which the chromophore is fully or partially constituted by acridine or by 9-acridone ring systems: from the pyrimido[5,6,1-de]acridines, to the pyrimido[4,5,6-kl]acridines, the bis(amine-functionalized) 9-acridone-4-carboxamides, the bis(amine-functionalized) acridine-4-carboxamides, and the pyrazolo[3,4,5- kl]acridine-5-carboxamides. In the present revue we will describe the rational design, the synthesis, and the salient biological characteristics of these classes of acridine derivatives.

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