Publisher： Bentham Science Publishers
E-ISSN： 1873-4294|12|9|971-993
ISSN： 1568-0266
Source： Current Topics in Medicinal Chemistry, Vol.12, Iss.9, 2012-05, pp. : 971-993
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Abstract
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) controlling physiological processes as learning and memory. However, the overactivation of glutamatergic neurotransmission is often related to various CNS chronic and acute diseases (epilepsy, ischaemia, Parkinson, etc.). This review will focus on the chemical structures, mechanism of action and main structure-activity relationships of anticonvulsant agents acting through glutamate neurotransmission.
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