Publisher: Bentham Science Publishers
E-ISSN: 1873-4286|19|6|1068-1084
ISSN: 1381-6128
Source: Current Pharmaceutical Design, Vol.19, Iss.6, 2013-02, pp. : 1068-1084
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The deregulated proteolysis is associated with various diseases in humans. Proteases are commonly regarded as the therapeutic targets. Almost one-third of all proteolytic enzymes in humans are serine proteases. This work provides a brief characteristic of the proteinaceous natural inhibitors, mostly of serine proteases. The examples of some classical and recently identified canonical and noncanonical inhibitors as well as serpins are described. Their actual and potential therapeutic applications are discussed.
Related content
Targeting Serine Proteases in Asthma
Current Topics in Medicinal Chemistry, Vol. 6, Iss. 4, 2006-02 ,pp. :