Publisher: Bentham Science Publishers
E-ISSN: 1875-5607|5|6|575-584
ISSN: 1389-5575
Source: Mini Reviews in Medicinal Chemistry, Vol.5, Iss.6, 2005-06, pp. : 575-584
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The migration of leukocytes from the blood stream to sites of infection is a key event in cellular immune response, mediated by multiple types of molecules including several adhesion receptors. The inhibition of adhesion receptors holds great promise for novel therapeutical strategies to treat chronic inflammatory disorders or autoimmune diseases. This review reports on recent advances in adhesion-based therapeutics and focuses on structural classification of selectin and integrin inhibitors.
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