Publisher: Bentham Science Publishers
E-ISSN: 1875-676x|10|1|20-29
ISSN: 1573-4129
Source: Current Pharmaceutical Analysis, Vol.10, Iss.1, 2014-02, pp. : 20-29
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The influence of addition of dsDNA on the electrocatalytic effect of carbon matrices, e.g. synthetic monocrystalline diamond, fullerenes C60 and multi-walled carbon nanotubes was studied. Three neurotransmitters: dopamine, epinephrine and norepinephrine, which are known as biomarkers that play an important role in transporting and modulating nervous impulses in the synapse were chosen as model analytes. Cyclic voltammetry was used to determine the optimum working conditions with a phosphate buffer solution at a pH=4 with KNO3 as support electrolyte. Differential pulse voltammograms (DPVs) were employed to assess the electrolytic effect of dsDNA on carbon matrices under the optimized conditions, and the potential applications of the biosensors for pharmaceutical and biomedical analysis.
Related content
Selection of An Unnatural Peptide Library For dsDNA Binding
Current Medicinal Chemistry, Vol. 8, Iss. 5, 2000-05 ,pp. :
Innovative Immobilization Matrices
Current Pharmaceutical Biotechnology, Vol. 17, Iss. 5, 2016-04 ,pp. :
Electrochemical MIP-Sensors for Drugs
Current Medicinal Chemistry, Vol. 25, Iss. 33, 2018-10 ,pp. :
Electrochemical DNA Biosensors in Drug Analysis
Current Pharmaceutical Analysis, Vol. 13, Iss. 3, 2017-04 ,pp. :