Publisher： Bentham Science Publishers
E-ISSN： 1873-4286|16|16|1843-1862
ISSN： 1381-6128
Source： Current Pharmaceutical Design, Vol.16, Iss.16, 2010-06, pp. : 1843-1862
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Protein tyrosine phosphatases (PTPs) are a diverse family of enzymes encoded by 107 genes in the human genome. Together with protein tyrosine kinases (PTKs), PTPs regulate various cellular activities essential for the initiation and maintenance of malignant phenotypes. While PTK inhibitors are now used routinely for cancer treatment, the PTP inhibitor development field is still in the discovery phase. In this article, the suitability of targeting PTPs for novel anticancer drug discovery is discussed. Examples are presented for PTPs that have been targeted for anticancer drug discovery as well as potential new PTP targets for novel anticancer drug discovery.
Related content
Drug Discovery and Protein Tyrosine Phosphatases
Current Medicinal Chemistry, Vol. 16, Iss. 17, 2009-06 ,pp. :
Access to resources
Recommend
Protein Tyrosine Phosphatases and their Inhibitors
Current Medicinal Chemistry, Vol. 12, Iss. 1, 2005-01 ,pp. :
Anticancer Drug Discovery Targeting DNA Hypermethylation
Current Medicinal Chemistry, Vol. 15, Iss. 14, 2008-06 ,pp. :