Biotransformation of Vulgarin

Publisher: Bentham Science Publishers

E-ISSN: 1875-5607|13|5|777-782

ISSN: 1389-5575

Source: Mini Reviews in Medicinal Chemistry, Vol.13, Iss.5, 2013-04, pp. : 777-782

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Abstract

Using a standard two-stage fermentation technique, the fungus Beauveria bassiana (ATCC 7159) was found to convert the eudesmanolide vulgarin (1) to 1,4-dihydroxy-5H,6,11&bgr;H-eudesman-6,12-olide (2). The use of the yeast Hansenula anomala ATCC 20170 instead, produced the less polar 4-hydroxy-1-oxo-5H,6,11&bgr;H-eudesman-6,12-olide (3), in addition to the more polar 3,4-dihydroxy-1-oxo-5H,6,11&bgr;H-eudesman-6,12-olide (4). These metabolites were characterized on the basis of their spectral data and the identity of 4 was further confirmed by chemical synthesis.